                         SEQUENCE LISTING

<110>  MURDOCH CHILDRENS RESEARCH INSTITUTE
 
<120>  MODIFIED HUMAN ROTAVIRUSES AND USES THEREFOR

<130>  35206595/EJH

<150>  AU 2012903702
<151>  2012-02-27

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  35
<212>  DNA
<213>  artificial

<220>
<223>  Primer - JCV1 VP1 5'UTR

<400>  1
tgtaaaacga cggccagtgg ctattaaagc tgtac                                  35


<210>  2
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN-VP1R

<400>  2
ggtcacatct aagcgytc                                                     18


<210>  3
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN-VP2F

<400>  3
ggctattraa ggytcaatgg                                                   20


<210>  4
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN-VP2R

<400>  4
ggtcatatct ccacartgg                                                    19


<210>  5
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN-VP3F

<400>  5
ggctwttaaa gcagtacca                                                    19


<210>  6
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN-VP3R

<400>  6
ggycacatca tgactagtg                                                    19


<210>  7
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Primer - JP 1 for g4 RV3

<400>  7
ggctataaaa tggcttcact c                                                 21


<210>  8
<211>  35
<212>  DNA
<213>  artificial

<220>
<223>  Primer - JCV1 VP3 3'UTR

<400>  8
caggaaacag ctatgaccgg tcacatycct cratr                                  35


<210>  9
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN VP6F

<400>  9
ggctttwaaa cgaagaagtc tt                                                22


<210>  10
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN VP6R

<400>  10
ggtcacatcc tctcact                                                      17


<210>  11
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  Primer - Beg9

<400>  11
ggctttaaaa gagagaattt ccgtctgg                                          28


<210>  12
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Primer - End9

<400>  12
ggtcacatca tacaattcta atctaag                                           27


<210>  13
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Primer - JCV1 NSP1 5'UTR

<400>  13
tgtaaaacga cggccagtta tgaaaagtct tgtggaagc                              39


<210>  14
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  Primer - JCV1 NSP1 3'UTR

<400>  14
caggaaacag ctatgaccca ttttatgctg cctaggcg                               38


<210>  15
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GeN-NSP2F

<400>  15
ggcttttaaa gcgtctcag                                                    19


<210>  16
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN-NSP2R

<400>  16
ggtcacataa gcgctttc                                                     18


<210>  17
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Prinmer - GEN-NSP3F

<400>  17
ggcttttaat gcttttcagt g                                                 21


<210>  18
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GEN-NSP3R

<400>  18
acataacgcc cctatagc                                                     18


<210>  19
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Primer - 10.1

<400>  19
ggcttttaaa agttctgttc c                                                 21


<210>  20
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Primer - 10.2

<400>  20
ggtcacacta agaccattcc                                                   20


<210>  21
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GeN-NSP5F

<400>  21
ggctttaaag cgctacag                                                     18


<210>  22
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  Primer - GeN-NSP5R

<400>  22
ggtcacaaaa cgggagt                                                      17


<210>  23
<211>  1461
<212>  DNA
<213>  artificial

<220>
<223>  MA104-RV3 VP7

<400>  23
atggctactt ttaaagatgc ttgttattat tataagagaa ttaacaagtt gaatcacgca       60

gtcttgaagt taggagttaa tgatacatgg agaccatcac ctccaactaa gtataaagga      120

tggtgtctgg attgttgcca acacactgat ttaacttact gtcgaggttg taccatgtat      180

catgtatgtc aatggtgtag tcaatatggt agatgctttc ttgatagtga accacatcta      240

ttaagaatga gaactttcaa gaatgaagtg acgaaaaatg atttaatgaa tttaattgac      300

atgtacaata cattatttcc tataaatcaa agaatagtag ataaattcat taatagtaca      360

agacaacata aatgtagaaa tgaatgtatg acacagtggt acaatcactt agtactacca      420

ataacattac agtctctatc aatcgaatta gatggtgata tttattacgt gtttggatat      480

tatgatagta tgaatgacat taatcaaact ccattctcat ttacaaattt aatagatatg      540

tatgataagt tgctacttga taatataaat tttaacagaa tgtcattctt accagtagca      600

ttacaacaag aatatgcact cagatatttt tcaaaatcaa ggtttattag tgaaaagagg      660

aaatgtatca gtgatgtaca tttttccgct agcgtaatag aaaatttaca caatccaagt      720

tttaagatac agattacacg caattgtagt gaattatcct ctgattggaa cggagcatgc      780

aaacttgtta aagatatgag cgcttatttt gatgtcctga aaacatcaca tattgaattt      840

tatagtattt caactagatg tagagtgttt acgcagtata aacttaaagt agcatctaag      900

catataaaac caaattatgt gacatcaaat catagaacat ctgcgactga ggtacataat      960

tgtaaatggt gctcaattaa tagtagttat actgtatgga atgattttag aattaagaag     1020

atatatgata acattttcaa ttttctacga gctttagtca aatcaaatgc taatgttgga     1080

cattgttcgt cacaggaaaa gatgtatgag catattgaag atgttctgga tgtatgtgat     1140

gatgaaaaat ggaaaatggc ggtaacagaa atattcaatt ggttagaacc agtagaactt     1200

aatactgtta aatatgttct gttcaatcat gaggtaaatt gggatgtcat taatttatta     1260

gttcagagta ttggtaaagt accacaaata ctgactttga atgatattgt cataattatg     1320

aaatctatca tatatgagtg gtttgatatc agatatatga ggaacacacc aatgactaca     1380

tttacagttg acaaattaag acggttatgc acaggagtga aggctgttga ttatgattcc     1440

ggcatatctg acgttgaata a                                               1461


<210>  24
<211>  486
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapted RV3 VP7

<400>  24

Met Ala Thr Phe Lys Asp Ala Cys Tyr Tyr Tyr Lys Arg Ile Asn Lys 
1               5                   10                  15      


Leu Asn His Ala Val Leu Lys Leu Gly Val Asn Asp Thr Trp Arg Pro 
            20                  25                  30          


Ser Pro Pro Thr Lys Tyr Lys Gly Trp Cys Leu Asp Cys Cys Gln His 
        35                  40                  45              


Thr Asp Leu Thr Tyr Cys Arg Gly Cys Thr Met Tyr His Val Cys Gln 
    50                  55                  60                  


Trp Cys Ser Gln Tyr Gly Arg Cys Phe Leu Asp Ser Glu Pro His Leu 
65                  70                  75                  80  


Leu Arg Met Arg Thr Phe Lys Asn Glu Val Thr Lys Asn Asp Leu Met 
                85                  90                  95      


Asn Leu Ile Asp Met Tyr Asn Thr Leu Phe Pro Ile Asn Gln Arg Ile 
            100                 105                 110         


Val Asp Lys Phe Ile Asn Ser Thr Arg Gln His Lys Cys Arg Asn Glu 
        115                 120                 125             


Cys Met Thr Gln Trp Tyr Asn His Leu Val Leu Pro Ile Thr Leu Gln 
    130                 135                 140                 


Ser Leu Ser Ile Glu Leu Asp Gly Asp Ile Tyr Tyr Val Phe Gly Tyr 
145                 150                 155                 160 


Tyr Asp Ser Met Asn Asp Ile Asn Gln Thr Pro Phe Ser Phe Thr Asn 
                165                 170                 175     


Leu Ile Asp Met Tyr Asp Lys Leu Leu Leu Asp Asn Ile Asn Phe Asn 
            180                 185                 190         


Arg Met Ser Phe Leu Pro Val Ala Leu Gln Gln Glu Tyr Ala Leu Arg 
        195                 200                 205             


Tyr Phe Ser Lys Ser Arg Phe Ile Ser Glu Lys Arg Lys Cys Ile Ser 
    210                 215                 220                 


Asp Val His Phe Ser Ala Ser Val Ile Glu Asn Leu His Asn Pro Ser 
225                 230                 235                 240 


Phe Lys Ile Gln Ile Thr Arg Asn Cys Ser Glu Leu Ser Ser Asp Trp 
                245                 250                 255     


Asn Gly Ala Cys Lys Leu Val Lys Asp Met Ser Ala Tyr Phe Asp Val 
            260                 265                 270         


Leu Lys Thr Ser His Ile Glu Phe Tyr Ser Ile Ser Thr Arg Cys Arg 
        275                 280                 285             


Val Phe Thr Gln Tyr Lys Leu Lys Val Ala Ser Lys His Ile Lys Pro 
    290                 295                 300                 


Asn Tyr Val Thr Ser Asn His Arg Thr Ser Ala Thr Glu Val His Asn 
305                 310                 315                 320 


Cys Lys Trp Cys Ser Ile Asn Ser Ser Tyr Thr Val Trp Asn Asp Phe 
                325                 330                 335     


Arg Ile Lys Lys Ile Tyr Asp Asn Ile Phe Asn Phe Leu Arg Ala Leu 
            340                 345                 350         


Val Lys Ser Asn Ala Asn Val Gly His Cys Ser Ser Gln Glu Lys Met 
        355                 360                 365             


Tyr Glu His Ile Glu Asp Val Leu Asp Val Cys Asp Asp Glu Lys Trp 
    370                 375                 380                 


Lys Met Ala Val Thr Glu Ile Phe Asn Trp Leu Glu Pro Val Glu Leu 
385                 390                 395                 400 


Asn Thr Val Lys Tyr Val Leu Phe Asn His Glu Val Asn Trp Asp Val 
                405                 410                 415     


Ile Asn Leu Leu Val Gln Ser Ile Gly Lys Val Pro Gln Ile Leu Thr 
            420                 425                 430         


Leu Asn Asp Ile Val Ile Ile Met Lys Ser Ile Ile Tyr Glu Trp Phe 
        435                 440                 445             


Asp Ile Arg Tyr Met Arg Asn Thr Pro Met Thr Thr Phe Thr Val Asp 
    450                 455                 460                 


Lys Leu Arg Arg Leu Cys Thr Gly Val Lys Ala Val Asp Tyr Asp Ser 
465                 470                 475                 480 


Gly Ile Ser Asp Val Glu 
                485     


<210>  25
<211>  1588
<212>  DNA
<213>  artificial

<220>
<223>  RV3-Vero VP7

<400>  25
tgtaaaacga cggccagtta tgaaaagtct tgtggaagcc atggctactt ttaaagatgc       60

ttgttattat tataagagaa ttaacaagtt gaatcacgca gtcttgaagt taggagttaa      120

tgatacatgg agaccatcac ctccaactaa gtataaagga tggtgtctgg attgttgcca      180

acacactgat ttaacttact gtcgaggttg taccatgtat catgtatgtc aatggtgtag      240

tcaatatggt agatgctttc ttgatagtga accacatcta ttaagaatga gaactttcaa      300

gaatgaagtg acgaaaaatg atttaatgaa tttaattgac atgtacaata cattatttcc      360

tataaatcaa agaatagtag ataaattcat taatagtaca agacaacata aatgtagaaa      420

tgaatgtatg acacagtggt acaatcactt agtactacca ataacattac agtctctatc      480

aatcgaatta gatggtgata tttattacgt gtttggatat tatgatagta tgaatgacat      540

taatcaaact ccattctcat ttacaaattt aatagatatg tatgataagt tgctacttga      600

taatataaat tttaacagaa tgtcattctt accagtagca ttacaacaag aatatgcact      660

cagatatttt tcaaaatcaa ggtttattag tgaaaagagg aaatgtatca gtgatgtaca      720

tttttccgct agcgtaatag aaaatttaca caatccaagt tttaagatac agattacacg      780

caattgtagt gaattatcct ctgattggaa cggagcatgc aaacttgtta aagatatgag      840

cgcttatttt gatgtcctga aaacatcaca tattgaattt tatagtattt caactagatg      900

tagagtgttt acgcagtata aacttaaagt agcatctaag catataaaac caaattatgt      960

gacatcaaat catagaacat ctgcgactga ggtacataat tgtaaatggt gctcaattaa     1020

tagtagttat actgtatgga atgattttag aattaagaag atatatgata acattttcaa     1080

ttttctacga gctttagtca aatcaaatgc taatgttgga cattgttcgt cacaggaaaa     1140

gatgtatgag catattgaag atgttctgga tgtatgtgat gatgaaaaat ggaaaatggc     1200

ggtaacagaa atattcaatt ggttagaacc agtagaactt aatactgtta aatatgttct     1260

gttcaatcat gaggtaaatt gggatgtcat taatttatta gttcagagta ttggtaaagt     1320

accacaaata ctgactttga atgatattgt cataattatg aaatctatca tatatgagtg     1380

gtttgatatc agatatatga ggaacacacc aatgactaca tttacagttg acaaattaag     1440

acggttatgc acaggagtga aggctgttga ttatgattcc ggcatatctg acgttgaata     1500

ctgaaataga ggtcacattt gccaccgcaa gactccctgc actagagtag cgcctaggca     1560

gcataaaatg ggtcatagct gtttcctg                                        1588


<210>  26
<211>  486
<212>  PRT
<213>  artificial

<220>
<223>  RV3-Vero VP7

<400>  26

Met Ala Thr Phe Lys Asp Ala Cys Tyr Tyr Tyr Lys Arg Ile Asn Lys 
1               5                   10                  15      


Leu Asn His Ala Val Leu Lys Leu Gly Val Asn Asp Thr Trp Arg Pro 
            20                  25                  30          


Ser Pro Pro Thr Lys Tyr Lys Gly Trp Cys Leu Asp Cys Cys Gln His 
        35                  40                  45              


Thr Asp Leu Thr Tyr Cys Arg Gly Cys Thr Met Tyr His Val Cys Gln 
    50                  55                  60                  


Trp Cys Ser Gln Tyr Gly Arg Cys Phe Leu Asp Ser Glu Pro His Leu 
65                  70                  75                  80  


Leu Arg Met Arg Thr Phe Lys Asn Glu Val Thr Lys Asn Asp Leu Met 
                85                  90                  95      


Asn Leu Ile Asp Met Tyr Asn Thr Leu Phe Pro Ile Asn Gln Arg Ile 
            100                 105                 110         


Val Asp Lys Phe Ile Asn Ser Thr Arg Gln His Lys Cys Arg Asn Glu 
        115                 120                 125             


Cys Met Thr Gln Trp Tyr Asn His Leu Val Leu Pro Ile Thr Leu Gln 
    130                 135                 140                 


Ser Leu Ser Ile Glu Leu Asp Gly Asp Ile Tyr Tyr Val Phe Gly Tyr 
145                 150                 155                 160 


Tyr Asp Ser Met Asn Asp Ile Asn Gln Thr Pro Phe Ser Phe Thr Asn 
                165                 170                 175     


Leu Ile Asp Met Tyr Asp Lys Leu Leu Leu Asp Asn Ile Asn Phe Asn 
            180                 185                 190         


Arg Met Ser Phe Leu Pro Val Ala Leu Gln Gln Glu Tyr Ala Leu Arg 
        195                 200                 205             


Tyr Phe Ser Lys Ser Arg Phe Ile Ser Glu Lys Arg Lys Cys Ile Ser 
    210                 215                 220                 


Asp Val His Phe Ser Ala Ser Val Ile Glu Asn Leu His Asn Pro Ser 
225                 230                 235                 240 


Phe Lys Ile Gln Ile Thr Arg Asn Cys Ser Glu Leu Ser Ser Asp Trp 
                245                 250                 255     


Asn Gly Ala Cys Lys Leu Val Lys Asp Met Ser Ala Tyr Phe Asp Val 
            260                 265                 270         


Leu Lys Thr Ser His Ile Glu Phe Tyr Ser Ile Ser Thr Arg Cys Arg 
        275                 280                 285             


Val Phe Thr Gln Tyr Lys Leu Lys Val Ala Ser Lys His Ile Lys Pro 
    290                 295                 300                 


Asn Tyr Val Thr Ser Asn His Arg Thr Ser Ala Thr Glu Val His Asn 
305                 310                 315                 320 


Cys Lys Trp Cys Ser Ile Asn Ser Ser Tyr Thr Val Trp Asn Asp Phe 
                325                 330                 335     


Arg Ile Lys Lys Ile Tyr Asp Asn Ile Phe Asn Phe Leu Arg Ala Leu 
            340                 345                 350         


Val Lys Ser Asn Ala Asn Val Gly His Cys Ser Ser Gln Glu Lys Met 
        355                 360                 365             


Tyr Glu His Ile Glu Asp Val Leu Asp Val Cys Asp Asp Glu Lys Trp 
    370                 375                 380                 


Lys Met Ala Val Thr Glu Ile Phe Asn Trp Leu Glu Pro Val Glu Leu 
385                 390                 395                 400 


Asn Thr Val Lys Tyr Val Leu Phe Asn His Glu Val Asn Trp Asp Val 
                405                 410                 415     


Ile Asn Leu Leu Val Gln Ser Ile Gly Lys Val Pro Gln Ile Leu Thr 
            420                 425                 430         


Leu Asn Asp Ile Val Ile Ile Met Lys Ser Ile Ile Tyr Glu Trp Phe 
        435                 440                 445             


Asp Ile Arg Tyr Met Arg Asn Thr Pro Met Thr Thr Phe Thr Val Asp 
    450                 455                 460                 


Lys Leu Arg Arg Leu Cys Thr Gly Val Lys Ala Val Asp Tyr Asp Ser 
465                 470                 475                 480 


Gly Ile Ser Asp Val Glu 
                485     


<210>  27
<211>  594
<212>  DNA
<213>  artificial

<220>
<223>  MA104 RV3 NSP5/6

<400>  27
atgtctctca gcattgacgt agcaagtctt ccctcaattt cttctagtat ctttaaaaat       60

gaatcgtctt ctacaacgtc aactctttct ggaaaatcta ttggtaggag tgaacagtac      120

atttcaccag atgcaggagc atttaataaa tacatgttgt cgaagtctcc agaggatatt      180

ggaccgtctg attctgcttc aaacgatcca ctcaccagct tttcgattag atcgaatgca      240

gttaaaacaa atgcagacgc tggcgtgtct atggattcat cgacgcaatc acgaccttca      300

agcaacgttg ggtgcgatca attggatttc tccttaacta aaggtattaa tgttagtgct      360

aatcttgatt catgtatatc aatttcaact gatcataaga aggagaaatc caagaaagat      420

aaaagtagga aacactaccc gagaattgaa gcagattctg attctgaaga ttatgttttg      480

gatgattcag atagtgatga cggtaaatgt aagaattgta aatataagaa aaaatatttc      540

gcactaagaa tgaggatgaa gcgagtcgca atgcaattga tcgaggattt gtaa            594


<210>  28
<211>  197
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapted RV3 NSP5/6

<400>  28

Met Ser Leu Ser Ile Asp Val Ala Ser Leu Pro Ser Ile Ser Ser Ser 
1               5                   10                  15      


Ile Phe Lys Asn Glu Ser Ser Ser Thr Thr Ser Thr Leu Ser Gly Lys 
            20                  25                  30          


Ser Ile Gly Arg Ser Glu Gln Tyr Ile Ser Pro Asp Ala Gly Ala Phe 
        35                  40                  45              


Asn Lys Tyr Met Leu Ser Lys Ser Pro Glu Asp Ile Gly Pro Ser Asp 
    50                  55                  60                  


Ser Ala Ser Asn Asp Pro Leu Thr Ser Phe Ser Ile Arg Ser Asn Ala 
65                  70                  75                  80  


Val Lys Thr Asn Ala Asp Ala Gly Val Ser Met Asp Ser Ser Thr Gln 
                85                  90                  95      


Ser Arg Pro Ser Ser Asn Val Gly Cys Asp Gln Leu Asp Phe Ser Leu 
            100                 105                 110         


Thr Lys Gly Ile Asn Val Ser Ala Asn Leu Asp Ser Cys Ile Ser Ile 
        115                 120                 125             


Ser Thr Asp His Lys Lys Glu Lys Ser Lys Lys Asp Lys Ser Arg Lys 
    130                 135                 140                 


His Tyr Pro Arg Ile Glu Ala Asp Ser Asp Ser Glu Asp Tyr Val Leu 
145                 150                 155                 160 


Asp Asp Ser Asp Ser Asp Asp Gly Lys Cys Lys Asn Cys Lys Tyr Lys 
                165                 170                 175     


Lys Lys Tyr Phe Ala Leu Arg Met Arg Met Lys Arg Val Ala Met Gln 
            180                 185                 190         


Leu Ile Glu Asp Leu 
        195         


<210>  29
<211>  664
<212>  DNA
<213>  artificial

<220>
<223>  RV3-Vero NSP5

<400>  29
ggcttttaaa gcgctacagt gatgtctctc agcattgacg tagcaagtct tccctcaatt       60

tcttctagta tctttaaaaa tgaatcgtct tctacaacgt caactctttc tggaaaatct      120

attggtagga gtgaacagta catttcacca gatgcagaag cattcaataa atacatgttg      180

tcgaagtctc cagaggatat tggaccgtct gattctgctt caaacgatcc actcaccagc      240

ttttcgatta gatcgaatgc agttaaaaca aatgcagacg ctggcgtgtc tatggattca      300

tcgacgcaat cacgaccttc aagcaacgtt gggtgcgatc aattggattt ctccataact      360

aaaggtatta atgttagtgc taatcttgat tcatgtatat caatttcaac tgatcataag      420

aaggagaaat ccaagaaaga taaaagtagg aaacactacc cgagaattga agcagattct      480

gattctgaag attatgtttt ggatgattca gatagtgatg acggtaaatg taagaattgt      540

aaatataaga aaaaatattt cgcactaaga atgaggatga agcgagtcgc aatgcaattg      600

atcgaggatt tgtaatgtca acctgagagc acactaggga gctccccact cccgttttgt      660

gacc                                                                   664


<210>  30
<211>  197
<212>  PRT
<213>  artificial

<220>
<223>  RV3-Vero NSP5

<400>  30

Met Ser Leu Ser Ile Asp Val Ala Ser Leu Pro Ser Ile Ser Ser Ser 
1               5                   10                  15      


Ile Phe Lys Asn Glu Ser Ser Ser Thr Thr Ser Thr Leu Ser Gly Lys 
            20                  25                  30          


Ser Ile Gly Arg Ser Glu Gln Tyr Ile Ser Pro Asp Ala Glu Ala Phe 
        35                  40                  45              


Asn Lys Tyr Met Leu Ser Lys Ser Pro Glu Asp Ile Gly Pro Ser Asp 
    50                  55                  60                  


Ser Ala Ser Asn Asp Pro Leu Thr Ser Phe Ser Ile Arg Ser Asn Ala 
65                  70                  75                  80  


Val Lys Thr Asn Ala Asp Ala Gly Val Ser Met Asp Ser Ser Thr Gln 
                85                  90                  95      


Ser Arg Pro Ser Ser Asn Val Gly Cys Asp Gln Leu Asp Phe Ser Ile 
            100                 105                 110         


Thr Lys Gly Ile Asn Val Ser Ala Asn Leu Asp Ser Cys Ile Ser Ile 
        115                 120                 125             


Ser Thr Asp His Lys Lys Glu Lys Ser Lys Lys Asp Lys Ser Arg Lys 
    130                 135                 140                 


His Tyr Pro Arg Ile Glu Ala Asp Ser Asp Ser Glu Asp Tyr Val Leu 
145                 150                 155                 160 


Asp Asp Ser Asp Ser Asp Asp Gly Lys Cys Lys Asn Cys Lys Tyr Lys 
                165                 170                 175     


Lys Lys Tyr Phe Ala Leu Arg Met Arg Met Lys Arg Val Ala Met Gln 
            180                 185                 190         


Leu Ile Glu Asp Leu 
        195         


<210>  31
<211>  954
<212>  DNA
<213>  artificial

<220>
<223>  MA104 RV3 NSP2

<400>  31
atggctgagc tagcttgctt ttgttatcct catttagaga acgatagcta taaatttatt       60

cctttcaata gtttggcaat aaaatgtatg ttgacagcta aagtggataa gaaagatcaa      120

gataaatttt ataattctat tgtatacgga attgcgccac caccacaatt caaaaaacgt      180

tataatacta gtgataattc aagaggcatg aattatgaaa caactatgtt taataaggtg      240

gctattttaa tttgtgaagc acttaattca attaaagtca ctcaatctga cattgctaat      300

gtcctctcaa gagtagtttc tattagacat ttggaaaatt tggtgttaag aaaagaaaat      360

catcaagatg tgctgtttca ttcgaaggag ctactcttaa aatccgtttt gatagctatt      420

ggtcaatcaa aagaaattga aactactgct actgccgagg gaggagaaat agtgttccaa      480

aatgcagctt ttactatgtg gaaattgact tatttagatc ataaactaac gcctattttg      540

gaccaaaatt ttatcgaata taagattaca ttaaatgaag ataaaccaat ttcagatgta      600

tgtgttaaag aacttgttgc tgaattgaga tggcagtata acagatttgc tgtaataacg      660

catggtaaag gtcactatag agtcgttaaa tattcatcag ttgctaatca cgcagataga      720

gtatttgtcg catacaaaaa taatgctaag agtggtaatg ttattaattt taatttactg      780

gatcaaagaa taatttggca aaattggtac gcatttacat cttcaatgaa acaaggtaat      840

acacttgaag tatgtaagaa actgctcttt caaaagatga agcaggagaa gaatccattt      900

aaaggactgt caactgatag aaaaatggat gaagtctcac atgttggagt ttag            954


<210>  32
<211>  317
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapted RV3 NSP2

<400>  32

Met Ala Glu Leu Ala Cys Phe Cys Tyr Pro His Leu Glu Asn Asp Ser 
1               5                   10                  15      


Tyr Lys Phe Ile Pro Phe Asn Ser Leu Ala Ile Lys Cys Met Leu Thr 
            20                  25                  30          


Ala Lys Val Asp Lys Lys Asp Gln Asp Lys Phe Tyr Asn Ser Ile Val 
        35                  40                  45              


Tyr Gly Ile Ala Pro Pro Pro Gln Phe Lys Lys Arg Tyr Asn Thr Ser 
    50                  55                  60                  


Asp Asn Ser Arg Gly Met Asn Tyr Glu Thr Thr Met Phe Asn Lys Val 
65                  70                  75                  80  


Ala Ile Leu Ile Cys Glu Ala Leu Asn Ser Ile Lys Val Thr Gln Ser 
                85                  90                  95      


Asp Ile Ala Asn Val Leu Ser Arg Val Val Ser Ile Arg His Leu Glu 
            100                 105                 110         


Asn Leu Val Leu Arg Lys Glu Asn His Gln Asp Val Leu Phe His Ser 
        115                 120                 125             


Lys Glu Leu Leu Leu Lys Ser Val Leu Ile Ala Ile Gly Gln Ser Lys 
    130                 135                 140                 


Glu Ile Glu Thr Thr Ala Thr Ala Glu Gly Gly Glu Ile Val Phe Gln 
145                 150                 155                 160 


Asn Ala Ala Phe Thr Met Trp Lys Leu Thr Tyr Leu Asp His Lys Leu 
                165                 170                 175     


Thr Pro Ile Leu Asp Gln Asn Phe Ile Glu Tyr Lys Ile Thr Leu Asn 
            180                 185                 190         


Glu Asp Lys Pro Ile Ser Asp Val Cys Val Lys Glu Leu Val Ala Glu 
        195                 200                 205             


Leu Arg Trp Gln Tyr Asn Arg Phe Ala Val Ile Thr His Gly Lys Gly 
    210                 215                 220                 


His Tyr Arg Val Val Lys Tyr Ser Ser Val Ala Asn His Ala Asp Arg 
225                 230                 235                 240 


Val Phe Val Ala Tyr Lys Asn Asn Ala Lys Ser Gly Asn Val Ile Asn 
                245                 250                 255     


Phe Asn Leu Leu Asp Gln Arg Ile Ile Trp Gln Asn Trp Tyr Ala Phe 
            260                 265                 270         


Thr Ser Ser Met Lys Gln Gly Asn Thr Leu Glu Val Cys Lys Lys Leu 
        275                 280                 285             


Leu Phe Gln Lys Met Lys Gln Glu Lys Asn Pro Phe Lys Gly Leu Ser 
    290                 295                 300                 


Thr Asp Arg Lys Met Asp Glu Val Ser His Val Gly Val 
305                 310                 315         


<210>  33
<211>  1059
<212>  DNA
<213>  artificial

<220>
<223>  RV3-VEro NSP2

<400>  33
ggcttttaaa gcgtctcagt cgccgtttga gccttgcggt gtagccatgg ctgagctagc       60

ttgcttttgt tatcctcatt tagagaacga tagctataaa tttattcctt tcaatagttt      120

ggcaataaaa tgtatgttga cagctaaagt ggataagaaa gatcaagata aattttataa      180

ttctattgta tacggaattg cgccaccacc acaattcaaa aaacgttata atactagtga      240

taattcaaga ggcatgaatt atgaaacaac tatgtttaat aaggtggcta ttttaatttg      300

tgaagcactt aattcaatta aagtcactca atctgacatt gctaatgtcc tctcaagagt      360

agtttctatt agacatttgg aaaatttggt gttaagaaaa gaaaatcatc aagatgtgct      420

gtttcattcg aaagagctac tcttaaaatc cgttttgata gctattggtc aatcaaaaga      480

aattgaaact actgctactg ccgagggagg agaaatagtg ttccaaaatg cagcttttac      540

tatgtggaaa ttgacttatt tagatcataa actaacgcct attttggacc aaaattttat      600

cgaatataag attacattaa atgaagataa accaatttca gatgtatgtg ttaaagaact      660

tgttgctgaa ttgagatggc agtataacag atttgctgta ataacgcatg gtaaaggtca      720

ctatagagtc gttaaatatt catcagttgc taatcacgca gatagagtat ttgtcgcata      780

caaaaataat gctaagagtg gtaatgttat taattttaat ttactggatc aaagaataat      840

ttggcaaaat tggtacgcat ttacatcttc aatgaaacaa ggtaatacac ttgaagtatg      900

taagaaactg ctctttcaaa agatgaagca ggagaagaat ccatttaaag gactgtcaac      960

tgatagaaaa atggatgaag tctcacatgt tggagtttag ttcgctttcg atttgaaaat     1020

gatgatgacg aagcaggaat agaaagcgct tatgtgacc                            1059


<210>  34
<211>  317
<212>  PRT
<213>  artificial

<220>
<223>  RV3-Vero NSP2

<400>  34

Met Ala Glu Leu Ala Cys Phe Cys Tyr Pro His Leu Glu Asn Asp Ser 
1               5                   10                  15      


Tyr Lys Phe Ile Pro Phe Asn Ser Leu Ala Ile Lys Cys Met Leu Thr 
            20                  25                  30          


Ala Lys Val Asp Lys Lys Asp Gln Asp Lys Phe Tyr Asn Ser Ile Val 
        35                  40                  45              


Tyr Gly Ile Ala Pro Pro Pro Gln Phe Lys Lys Arg Tyr Asn Thr Ser 
    50                  55                  60                  


Asp Asn Ser Arg Gly Met Asn Tyr Glu Thr Thr Met Phe Asn Lys Val 
65                  70                  75                  80  


Ala Ile Leu Ile Cys Glu Ala Leu Asn Ser Ile Lys Val Thr Gln Ser 
                85                  90                  95      


Asp Ile Ala Asn Val Leu Ser Arg Val Val Ser Ile Arg His Leu Glu 
            100                 105                 110         


Asn Leu Val Leu Arg Lys Glu Asn His Gln Asp Val Leu Phe His Ser 
        115                 120                 125             


Lys Glu Leu Leu Leu Lys Ser Val Leu Ile Ala Ile Gly Gln Ser Lys 
    130                 135                 140                 


Glu Ile Glu Thr Thr Ala Thr Ala Glu Gly Gly Glu Ile Val Phe Gln 
145                 150                 155                 160 


Asn Ala Ala Phe Thr Met Trp Lys Leu Thr Tyr Leu Asp His Lys Leu 
                165                 170                 175     


Thr Pro Ile Leu Asp Gln Asn Phe Ile Glu Tyr Lys Ile Thr Leu Asn 
            180                 185                 190         


Glu Asp Lys Pro Ile Ser Asp Val Cys Val Lys Glu Leu Val Ala Glu 
        195                 200                 205             


Leu Arg Trp Gln Tyr Asn Arg Phe Ala Val Ile Thr His Gly Lys Gly 
    210                 215                 220                 


His Tyr Arg Val Val Lys Tyr Ser Ser Val Ala Asn His Ala Asp Arg 
225                 230                 235                 240 


Val Phe Val Ala Tyr Lys Asn Asn Ala Lys Ser Gly Asn Val Ile Asn 
                245                 250                 255     


Phe Asn Leu Leu Asp Gln Arg Ile Ile Trp Gln Asn Trp Tyr Ala Phe 
            260                 265                 270         


Thr Ser Ser Met Lys Gln Gly Asn Thr Leu Glu Val Cys Lys Lys Leu 
        275                 280                 285             


Leu Phe Gln Lys Met Lys Gln Glu Lys Asn Pro Phe Lys Gly Leu Ser 
    290                 295                 300                 


Thr Asp Arg Lys Met Asp Glu Val Ser His Val Gly Val 
305                 310                 315         


<210>  35
<211>  528
<212>  DNA
<213>  artificial

<220>
<223>  MA104-derived RV3 NSP4

<400>  35
atggataagc ttgccgacct caactacaca ttgagtgtaa tcactttaat gaatgacaca       60

ttgcattcta taattcaaga tcctggaatg gcgtatttta catatattgc atctgttcta      120

acagttttgt tcacattaca caaagcttca attccagcca tgaaaatagc attgaaaaca      180

tcaaaatgtt catataaagt aattaaatat tgtatagtca cgataattaa tactctttta      240

aaattggctg gatgtaaaga gcaggttact acaaaagacg aaattgagca acagatggac      300

agaattgtta aagagatgag acgtcagctg gagatgattg ataaactaac tactcgtgaa      360

attgaacagg ttgaattgct taaatgtata tatgacaacc tgataactag accagttaac      420

gttatagata tgtcgaagga attcaatcaa aaaaacatca aaacgctaga tgaatgggag      480

agtgtaaaaa atccatatga accgtcagaa gtgactgcat ccatgtaa                   528


<210>  36
<211>  175
<212>  PRT
<213>  artificial

<220>
<223>  RV3 NSP4

<400>  36

Met Asp Lys Leu Ala Asp Leu Asn Tyr Thr Leu Ser Val Ile Thr Leu 
1               5                   10                  15      


Met Asn Asp Thr Leu His Ser Ile Ile Gln Asp Pro Gly Met Ala Tyr 
            20                  25                  30          


Phe Thr Tyr Ile Ala Ser Val Leu Thr Val Leu Phe Thr Leu His Lys 
        35                  40                  45              


Ala Ser Ile Pro Ala Met Lys Ile Ala Leu Lys Thr Ser Lys Cys Ser 
    50                  55                  60                  


Tyr Lys Val Ile Lys Tyr Cys Ile Val Thr Ile Ile Asn Thr Leu Leu 
65                  70                  75                  80  


Lys Leu Ala Gly Cys Lys Glu Gln Val Thr Thr Lys Asp Glu Ile Glu 
                85                  90                  95      


Gln Gln Met Asp Arg Ile Val Lys Glu Met Arg Arg Gln Leu Glu Met 
            100                 105                 110         


Ile Asp Lys Leu Thr Thr Arg Glu Ile Glu Gln Val Glu Leu Leu Lys 
        115                 120                 125             


Cys Ile Tyr Asp Asn Leu Ile Thr Arg Pro Val Asn Val Ile Asp Met 
    130                 135                 140                 


Ser Lys Glu Phe Asn Gln Lys Asn Ile Lys Thr Leu Asp Glu Trp Glu 
145                 150                 155                 160 


Ser Val Lys Asn Pro Tyr Glu Pro Ser Glu Val Thr Ala Ser Met 
                165                 170                 175 


<210>  37
<211>  749
<212>  DNA
<213>  artificial

<220>
<223>  RV3-Vero NSP4

<400>  37
ggcttttaaa agttctgtcc gagagagcgc gtgcggaaag atggataagc ttgccgacct       60

caactacaca ttgagtgtaa tcactttaat gaatgacaca ttgcattcta taattcaaga      120

tcctggaatg gcgtatttta catatattgc atctgttcta acagttttgt tcacattaca      180

caaagcttca attccaacca tgaaaatagc attgaaaaca tcaaaatgtt catataaagt      240

aattaaatat tgtatagtca cgataactaa tactctttta aaattggctg gatataaaga      300

gcaggttact acaaaagacg aaattgagca acagatggac agaattgtta aagagatgag      360

acgtcagctg gagatgattg ataaactaac tactcgtgaa attgaacagg ttgaattgct      420

taaatgtata tatgacaacc tgataactag accagttaac gttatagata tgtcgaagga      480

attcaatcaa aaaaacatca aaacgctaga tgaatgggag agtggaaaaa atctatatga      540

accgtcagaa gtgactgcat ccatgtaaga ggttgagttg ccgtcgtctg tcttcggaag      600

cggcggaact cttcaccgca agccccatta gacctgatga ttgactgaga agccacagtc      660

aatcatatcg cgtgtggctc agccttaatc ccgtttaacc aatccagcga gtgttggacg      720

ttaatggaag gaatggtctt agtgtgacc                                        749


<210>  38
<211>  175
<212>  PRT
<213>  artificial

<220>
<223>  RV3-Vero NSP4

<400>  38

Met Asp Lys Leu Ala Asp Leu Asn Tyr Thr Leu Ser Val Ile Thr Leu 
1               5                   10                  15      


Met Asn Asp Thr Leu His Ser Ile Ile Gln Asp Pro Gly Met Ala Tyr 
            20                  25                  30          


Phe Thr Tyr Ile Ala Ser Val Leu Thr Val Leu Phe Thr Leu His Lys 
        35                  40                  45              


Ala Ser Ile Pro Thr Met Lys Ile Ala Leu Lys Thr Ser Lys Cys Ser 
    50                  55                  60                  


Tyr Lys Val Ile Lys Tyr Cys Ile Val Thr Ile Thr Asn Thr Leu Leu 
65                  70                  75                  80  


Lys Leu Ala Gly Tyr Lys Glu Gln Val Thr Thr Lys Asp Glu Ile Glu 
                85                  90                  95      


Gln Gln Met Asp Arg Ile Val Lys Glu Met Arg Arg Gln Leu Glu Met 
            100                 105                 110         


Ile Asp Lys Leu Thr Thr Arg Glu Ile Glu Gln Val Glu Leu Leu Lys 
        115                 120                 125             


Cys Ile Tyr Asp Asn Leu Ile Thr Arg Pro Val Asn Val Ile Asp Met 
    130                 135                 140                 


Ser Lys Glu Phe Asn Gln Lys Asn Ile Lys Thr Leu Asp Glu Trp Glu 
145                 150                 155                 160 


Ser Gly Lys Asn Leu Tyr Glu Pro Ser Glu Val Thr Ala Ser Met 
                165                 170                 175 


<210>  39
<211>  1194
<212>  DNA
<213>  artificial

<220>
<223>  MA104-derived RV3 VP6

<400>  39
atggaggttc tgtattcatt gtcaaaaact cttaaagatg ctagggataa gattgttgaa       60

ggtacattat attctaatgt tagtgatctc attcagcaat ttaatcaaat gatagtaacc      120

atgaatggaa atgactttca aactggagga attggcaatt tacctattag aaattggaca      180

tttgactttg gtctactagg tactacgctg ttaaaccttg atgctaatta cgttgagacc      240

gcaagaacta caattaagta ttttattgac tttattgata atgtatgtat ggatgaaatg      300

gcaagagagt ctcaaagaaa tggagtagct ccacaatctg aggcattgag gaagctagcc      360

ggtattaaat ttaaaagaat aaattttaat aattcatcag aatatataga aaattggaat      420

ttacaaaata gaagacagcg taccggattt gttttccata aacctaatat atttccatac      480

tcagcatcat ttactttaaa taggtctcaa ccaatgcatg acaatttaat gggaaccatg      540

tggcttaacg ctggatcaga aattcaagtg gctggatttg actactcgtg tgccctaaat      600

gctccagcaa atattcagca gtttgaacat attgtccagc ttaggcgtgc gctaactaca      660

gctactataa ctttgctacc tgatgcagaa agatttagtt ttccaagagt tattaattca      720

gcagatggcg caaccacatg gttctttaat ccaattatcc taagaccaaa caatgtagag      780

gtagaatttt tactgaatgg acaaattatt aatacatatc aagctagatt tggcactatt      840

atcgcaagaa attttgatac aattcgtcta tcattccaat taatgcgtcc accaaacatg      900

acgccagccg taaatgcatt atttccgcaa gcacaacctt ttcaacatca tgcaacagtt      960

ggacttacgt tacgtattga gtctgcagtt tgtgaatcag tgcttgcgga tgcaaatgaa     1020

actttattgg cgaatgttac tgcagtacgt caagagtatg ctataccggt tggaccagta     1080

tttccaccag gcatgaattg gactgagctg attactaact attcaccatc cagggaagat     1140

aatttgcaac gtgtctttac agtagcctct atcagaagca tgttaattaa gtga           1194


<210>  40
<211>  397
<212>  PRT
<213>  artificial

<220>
<223>  MA104-derived RV3 VP6

<400>  40

Met Glu Val Leu Tyr Ser Leu Ser Lys Thr Leu Lys Asp Ala Arg Asp 
1               5                   10                  15      


Lys Ile Val Glu Gly Thr Leu Tyr Ser Asn Val Ser Asp Leu Ile Gln 
            20                  25                  30          


Gln Phe Asn Gln Met Ile Val Thr Met Asn Gly Asn Asp Phe Gln Thr 
        35                  40                  45              


Gly Gly Ile Gly Asn Leu Pro Ile Arg Asn Trp Thr Phe Asp Phe Gly 
    50                  55                  60                  


Leu Leu Gly Thr Thr Leu Leu Asn Leu Asp Ala Asn Tyr Val Glu Thr 
65                  70                  75                  80  


Ala Arg Thr Thr Ile Lys Tyr Phe Ile Asp Phe Ile Asp Asn Val Cys 
                85                  90                  95      


Met Asp Glu Met Ala Arg Glu Ser Gln Arg Asn Gly Val Ala Pro Gln 
            100                 105                 110         


Ser Glu Ala Leu Arg Lys Leu Ala Gly Ile Lys Phe Lys Arg Ile Asn 
        115                 120                 125             


Phe Asn Asn Ser Ser Glu Tyr Ile Glu Asn Trp Asn Leu Gln Asn Arg 
    130                 135                 140                 


Arg Gln Arg Thr Gly Phe Val Phe His Lys Pro Asn Ile Phe Pro Tyr 
145                 150                 155                 160 


Ser Ala Ser Phe Thr Leu Asn Arg Ser Gln Pro Met His Asp Asn Leu 
                165                 170                 175     


Met Gly Thr Met Trp Leu Asn Ala Gly Ser Glu Ile Gln Val Ala Gly 
            180                 185                 190         


Phe Asp Tyr Ser Cys Ala Leu Asn Ala Pro Ala Asn Ile Gln Gln Phe 
        195                 200                 205             


Glu His Ile Val Gln Leu Arg Arg Ala Leu Thr Thr Ala Thr Ile Thr 
    210                 215                 220                 


Leu Leu Pro Asp Ala Glu Arg Phe Ser Phe Pro Arg Val Ile Asn Ser 
225                 230                 235                 240 


Ala Asp Gly Ala Thr Thr Trp Phe Phe Asn Pro Ile Ile Leu Arg Pro 
                245                 250                 255     


Asn Asn Val Glu Val Glu Phe Leu Leu Asn Gly Gln Ile Ile Asn Thr 
            260                 265                 270         


Tyr Gln Ala Arg Phe Gly Thr Ile Ile Ala Arg Asn Phe Asp Thr Ile 
        275                 280                 285             


Arg Leu Ser Phe Gln Leu Met Arg Pro Pro Asn Met Thr Pro Ala Val 
    290                 295                 300                 


Asn Ala Leu Phe Pro Gln Ala Gln Pro Phe Gln His His Ala Thr Val 
305                 310                 315                 320 


Gly Leu Thr Leu Arg Ile Glu Ser Ala Val Cys Glu Ser Val Leu Ala 
                325                 330                 335     


Asp Ala Asn Glu Thr Leu Leu Ala Asn Val Thr Ala Val Arg Gln Glu 
            340                 345                 350         


Tyr Ala Ile Pro Val Gly Pro Val Phe Pro Pro Gly Met Asn Trp Thr 
        355                 360                 365             


Glu Leu Ile Thr Asn Tyr Ser Pro Ser Arg Glu Asp Asn Leu Gln Arg 
    370                 375                 380                 


Val Phe Thr Val Ala Ser Ile Arg Ser Met Leu Ile Lys 
385                 390                 395         


<210>  41
<211>  1359
<212>  DNA
<213>  artificial

<220>
<223>  RV3-Vero VP6

<400>  41
ggcttttaaa cgaagaagtc ttcgacatgg aggttctgta ttcattgtca aaaactctta       60

aagatgctag ggataagatt gttgaaggta cattatattc taatgttagt gatctcattc      120

agcaatttaa tcaaatgata gtaaccatga atggaaatga ctttcaaact ggaggaattg      180

gcaatttacc tattagaaat tggacatttg actttggtct actaggtact acgctgttaa      240

accttgatgc taattacgtt gagaccgcaa gaactacaat taagtatttt attgacttta      300

ttgataatgt atgtatggat gaaatggcaa gagagtctca aagaaatgga gtagctccac      360

aatctgaggc attgaggaag ctagccggta ttaaatttaa aagaataaat tttaataatt      420

catcagaata tatagaaaat tggaatttac aaaatagaag acagcgtacc ggatttgttt      480

tccataaacc taatatattt ccatactcag catcatttac tttaaatagg tctcaaccaa      540

tgcatgacaa tttaatggga accatgtggc ttaacgctgg atcagaaatt caagtggctg      600

gatttgacta ctcgtgtgcc ctaaatgctc cagcaaatat tcagcagttt gaacatattg      660

tccagcttag gcgtgcgcta actacagcta ctataacttt gctacctgat gcagaaagat      720

ttagttttcc aagagttatt aattcagcag atggcgcaac cacatggttc tttaatccaa      780

ttatcctaag accaaacaat gtagaggtag aatttttact gaatggacaa attattaata      840

catatcaagc tagatttggc actattatcg caagaaattt tgatacaatt cgtctatcat      900

tccaattaat gcgtccacca aacatgacgc cagccgtaaa tgcattattt ccgcaagcac      960

aaccttttca acatcatgca acagttggac ttacgttacg tattgagtct gcagtttgtg     1020

aatcagtgct tgcggatgca aatgaaactt tattggcgaa tgttactgca gtacgtcaag     1080

agtatgctat accggttgga ccagtatttc caccaggcat gaattggact gagctgatta     1140

ctaactattc accatccagg gaagataatt tgcaacgtgt ctttacagta gcctctatca     1200

gaagcatgtt aattaagtga ggaccagact aaccatctgg tatccaatct taattagcat     1260

gtagctatgt caagtcattc agactctaca agtaaggaca tgatttcatg ttcgctacgt     1320

agagtaactg catgaatgat gtagtgagag gatgtgacc                            1359


<210>  42
<211>  397
<212>  PRT
<213>  artificial

<220>
<223>  RV3-Vero VP6

<400>  42

Met Glu Val Leu Tyr Ser Leu Ser Lys Thr Leu Lys Asp Ala Arg Asp 
1               5                   10                  15      


Lys Ile Val Glu Gly Thr Leu Tyr Ser Asn Val Ser Asp Leu Ile Gln 
            20                  25                  30          


Gln Phe Asn Gln Met Ile Val Thr Met Asn Gly Asn Asp Phe Gln Thr 
        35                  40                  45              


Gly Gly Ile Gly Asn Leu Pro Ile Arg Asn Trp Thr Phe Asp Phe Gly 
    50                  55                  60                  


Leu Leu Gly Thr Thr Leu Leu Asn Leu Asp Ala Asn Tyr Val Glu Thr 
65                  70                  75                  80  


Ala Arg Thr Thr Ile Lys Tyr Phe Ile Asp Phe Ile Asp Asn Val Cys 
                85                  90                  95      


Met Asp Glu Met Ala Arg Glu Ser Gln Arg Asn Gly Val Ala Pro Gln 
            100                 105                 110         


Ser Glu Ala Leu Arg Lys Leu Ala Gly Ile Lys Phe Lys Arg Ile Asn 
        115                 120                 125             


Phe Asn Asn Ser Ser Glu Tyr Ile Glu Asn Trp Asn Leu Gln Asn Arg 
    130                 135                 140                 


Arg Gln Arg Thr Gly Phe Val Phe His Lys Pro Asn Ile Phe Pro Tyr 
145                 150                 155                 160 


Ser Ala Ser Phe Thr Leu Asn Arg Ser Gln Pro Met His Asp Asn Leu 
                165                 170                 175     


Met Gly Thr Met Trp Leu Asn Ala Gly Ser Glu Ile Gln Val Ala Gly 
            180                 185                 190         


Phe Asp Tyr Ser Cys Ala Leu Asn Ala Pro Ala Asn Ile Gln Gln Phe 
        195                 200                 205             


Glu His Ile Val Gln Leu Arg Arg Ala Leu Thr Thr Ala Thr Ile Thr 
    210                 215                 220                 


Leu Leu Pro Asp Ala Glu Arg Phe Ser Phe Pro Arg Val Ile Asn Ser 
225                 230                 235                 240 


Ala Asp Gly Ala Thr Thr Trp Phe Phe Asn Pro Ile Ile Leu Arg Pro 
                245                 250                 255     


Asn Asn Val Glu Val Glu Phe Leu Leu Asn Gly Gln Ile Ile Asn Thr 
            260                 265                 270         


Tyr Gln Ala Arg Phe Gly Thr Ile Ile Ala Arg Asn Phe Asp Thr Ile 
        275                 280                 285             


Arg Leu Ser Phe Gln Leu Met Arg Pro Pro Asn Met Thr Pro Ala Val 
    290                 295                 300                 


Asn Ala Leu Phe Pro Gln Ala Gln Pro Phe Gln His His Ala Thr Val 
305                 310                 315                 320 


Gly Leu Thr Leu Arg Ile Glu Ser Ala Val Cys Glu Ser Val Leu Ala 
                325                 330                 335     


Asp Ala Asn Glu Thr Leu Leu Ala Asn Val Thr Ala Val Arg Gln Glu 
            340                 345                 350         


Tyr Ala Ile Pro Val Gly Pro Val Phe Pro Pro Gly Met Asn Trp Thr 
        355                 360                 365             


Glu Leu Ile Thr Asn Tyr Ser Pro Ser Arg Glu Asp Asn Leu Gln Arg 
    370                 375                 380                 


Val Phe Thr Val Ala Ser Ile Arg Ser Met Leu Ile Lys 
385                 390                 395         


<210>  43
<211>  964
<212>  DNA
<213>  artificial

<220>
<223>  MA104-adapted RV3 NSP3

<400>  43
ttttaatgct tttcagtggt tgctgctcaa gatggagtct actcagcaga tggtaagctc       60

tattattaac acttcttttg aagctgcagt tgttgctgcc acttcaacat tagaattaat      120

gggtattcaa tatgattaca atgaagtatt tactagagtt aaaagtaaat ttgattatgt      180

gatggatgac tctggtgtta aaaacaatct tttgggtaaa gctataacta ttgatcaggc      240

gttaaatgga aagtttggct cagctattag aaatagaaat tggatgactg attctaaaac      300

ggttgctaaa ttagatgaag acgtgaataa acttagaatg acattatctt ctaaaggaat      360

cgaccaaaag atgagagtac ttaatgcttg ttttagtgta aaaagaatac caggaaaatc      420

atcatcaata attaaatgct ctagacttat gaaggataaa atagaacgtg gagaagttga      480

ggttgatgat tcatatgttg atgagaaaat ggaaattgat actattgatt ggaaatctcg      540

ttatgatcag ttagaaaaaa gatttgagtc actaaaacaa agagttaatg agaaatacaa      600

tacttgggta caaaaagcga agaaagtaaa tgaaaatatg tactctcttc agaatgtcat      660

ttcacaacag caaaaccaaa tagcagatct tcaacaatat tgtaataaat tggaagctga      720

tttgcaaggc aaatttagtt cattagtgtc atcagttgag tggtatctaa ggtctatgga      780

attgccaaat gatgtaaaga atgatattga acagcagtta aattcaattg atttaattaa      840

tcccattaat gctatagatg atatcgaatc attgattaga aatttaattc aagattatga      900

cagaacattt ttaatgttaa aaggactgtt gaagcaatgc aactatgaat atacatatga      960

gtag                                                                   964


<210>  44
<211>  310
<212>  PRT
<213>  artificial

<220>
<223>  MA104-derived RV3 NSP3

<400>  44

Met Glu Ser Thr Gln Gln Met Val Ser Ser Ile Ile Asn Thr Ser Phe 
1               5                   10                  15      


Glu Ala Ala Val Val Ala Ala Thr Ser Thr Leu Glu Leu Met Gly Ile 
            20                  25                  30          


Gln Tyr Asp Tyr Asn Glu Val Phe Thr Arg Val Lys Ser Lys Phe Asp 
        35                  40                  45              


Tyr Val Met Asp Asp Ser Gly Val Lys Asn Asn Leu Leu Gly Lys Ala 
    50                  55                  60                  


Ile Thr Ile Asp Gln Ala Leu Asn Gly Lys Phe Gly Ser Ala Ile Arg 
65                  70                  75                  80  


Asn Arg Asn Trp Met Thr Asp Ser Lys Thr Val Ala Lys Leu Asp Glu 
                85                  90                  95      


Asp Val Asn Lys Leu Arg Met Thr Leu Ser Ser Lys Gly Ile Asp Gln 
            100                 105                 110         


Lys Met Arg Val Leu Asn Ala Cys Phe Ser Val Lys Arg Ile Pro Gly 
        115                 120                 125             


Lys Ser Ser Ser Ile Ile Lys Cys Ser Arg Leu Met Lys Asp Lys Ile 
    130                 135                 140                 


Glu Arg Gly Glu Val Glu Val Asp Asp Ser Tyr Val Asp Glu Lys Met 
145                 150                 155                 160 


Glu Ile Asp Thr Ile Asp Trp Lys Ser Arg Tyr Asp Gln Leu Glu Lys 
                165                 170                 175     


Arg Phe Glu Ser Leu Lys Gln Arg Val Asn Glu Lys Tyr Asn Thr Trp 
            180                 185                 190         


Val Gln Lys Ala Lys Lys Val Asn Glu Asn Met Tyr Ser Leu Gln Asn 
        195                 200                 205             


Val Ile Ser Gln Gln Gln Asn Gln Ile Ala Asp Leu Gln Gln Tyr Cys 
    210                 215                 220                 


Asn Lys Leu Glu Ala Asp Leu Gln Gly Lys Phe Ser Ser Leu Val Ser 
225                 230                 235                 240 


Ser Val Glu Trp Tyr Leu Arg Ser Met Glu Leu Pro Asn Asp Val Lys 
                245                 250                 255     


Asn Asp Ile Glu Gln Gln Leu Asn Ser Ile Asp Leu Ile Asn Pro Ile 
            260                 265                 270         


Asn Ala Ile Asp Asp Ile Glu Ser Leu Ile Arg Asn Leu Ile Gln Asp 
        275                 280                 285             


Tyr Asp Arg Thr Phe Leu Met Leu Lys Gly Leu Leu Lys Gln Cys Asn 
    290                 295                 300                 


Tyr Glu Tyr Thr Tyr Glu 
305                 310 


<210>  45
<211>  1070
<212>  DNA
<213>  artificial

<220>
<223>  RV3-Vero NSP3

<400>  45
ggcttttaat gcttttcagt ggttgctgct caagatggag tctactcagc agatggtaag       60

ctctattatt aacacttctt ttgaagctgc agttgttgct gccacttcaa cattagaatt      120

aatgggtatt caatatgatt acaatgaagt atttactaga gttaaaagta aatttgatta      180

tgtgatggat gactctggtg ttaaaaacaa tcttttgggt aaagctataa ctattgatca      240

ggcgttaaat ggaaagtttg gctcagctat tagaaataga aattggatga ctgattctaa      300

aacggttgct aaattagatg aagacgtgaa taaacttaga atgacattat cttctaaagg      360

aatcgaccaa aagatgagag tacttaatgc ttgttttagt gtaaaaagaa taccaggaaa      420

atcatcatca ataattaaat gctctagact tatgaaggat aaaatagaac gtggagaagt      480

tgaggttgat gattcatatg ttgatgagaa aatggaaatt gatactattg attggaaatc      540

tcgttatgat cagttagaaa aaagatttga gtcactaaaa caaagagtta atgagaaata      600

caatacttgg gtacaaaaag cgaagaaagt aaatgaaaat atgtactctc ttcagaatgt      660

catttcacaa cagcaaaacc aaatagcaga tcttcaacaa tattgtaata aattggaagc      720

tgatttgcaa ggcaaattta gttcattagt gtcatcagtt gagtggtatc taaggtctat      780

ggaattgcca aatgatgtaa agaatgatat tgaacagcag ttaaattcaa ttgatttaat      840

taatcccatt aatgctatag atgatatcga atcattgatt agaaatttaa ttcaagatta      900

tgacagaaca tttttaatgt taaaaggact gttgaagcaa tgcaactatg aatatacata      960

tgagtagtca cataattaaa agtattaacc atctacacat gaccctctat gagcacaata     1020

gttaaaagct aacactgtca aaaacctaaa tggctatagg ggcgttatgt                1070


<210>  46
<211>  310
<212>  PRT
<213>  artificial

<220>
<223>  RV3 Vero NSP3

<400>  46

Met Glu Ser Thr Gln Gln Met Val Ser Ser Ile Ile Asn Thr Ser Phe 
1               5                   10                  15      


Glu Ala Ala Val Val Ala Ala Thr Ser Thr Leu Glu Leu Met Gly Ile 
            20                  25                  30          


Gln Tyr Asp Tyr Asn Glu Val Phe Thr Arg Val Lys Ser Lys Phe Asp 
        35                  40                  45              


Tyr Val Met Asp Asp Ser Gly Val Lys Asn Asn Leu Leu Gly Lys Ala 
    50                  55                  60                  


Ile Thr Ile Asp Gln Ala Leu Asn Gly Lys Phe Gly Ser Ala Ile Arg 
65                  70                  75                  80  


Asn Arg Asn Trp Met Thr Asp Ser Lys Thr Val Ala Lys Leu Asp Glu 
                85                  90                  95      


Asp Val Asn Lys Leu Arg Met Thr Leu Ser Ser Lys Gly Ile Asp Gln 
            100                 105                 110         


Lys Met Arg Val Leu Asn Ala Cys Phe Ser Val Lys Arg Ile Pro Gly 
        115                 120                 125             


Lys Ser Ser Ser Ile Ile Lys Cys Ser Arg Leu Met Lys Asp Lys Ile 
    130                 135                 140                 


Glu Arg Gly Glu Val Glu Val Asp Asp Ser Tyr Val Asp Glu Lys Met 
145                 150                 155                 160 


Glu Ile Asp Thr Ile Asp Trp Lys Ser Arg Tyr Asp Gln Leu Glu Lys 
                165                 170                 175     


Arg Phe Glu Ser Leu Lys Gln Arg Val Asn Glu Lys Tyr Asn Thr Trp 
            180                 185                 190         


Val Gln Lys Ala Lys Lys Val Asn Glu Asn Met Tyr Ser Leu Gln Asn 
        195                 200                 205             


Val Ile Ser Gln Gln Gln Asn Gln Ile Ala Asp Leu Gln Gln Tyr Cys 
    210                 215                 220                 


Asn Lys Leu Glu Ala Asp Leu Gln Gly Lys Phe Ser Ser Leu Val Ser 
225                 230                 235                 240 


Ser Val Glu Trp Tyr Leu Arg Ser Met Glu Leu Pro Asn Asp Val Lys 
                245                 250                 255     


Asn Asp Ile Glu Gln Gln Leu Asn Ser Ile Asp Leu Ile Asn Pro Ile 
            260                 265                 270         


Asn Ala Ile Asp Asp Ile Glu Ser Leu Ile Arg Asn Leu Ile Gln Asp 
        275                 280                 285             


Tyr Asp Arg Thr Phe Leu Met Leu Lys Gly Leu Leu Lys Gln Cys Asn 
    290                 295                 300                 


Tyr Glu Tyr Thr Tyr Glu 
305                 310 


<210>  47
<211>  3267
<212>  DNA
<213>  artificial

<220>
<223>  MA104-adapted RV3 VP1

<400>  47
atggggaagt acaatctaat cttgtcagaa tatttatcat ttgtttataa ttcacaatct       60

gcagttcaaa taccaattta ttattcttcc aattcagaat tagaaaaaag atgtattgaa      120

tttcatgcta aatgtgttga cagttcaaaa aaaggtctat cattaaaacc tttattcgaa      180

aaatataaag atgtaataga taatgcaact ttactatctc tattatcata ttcttatgat      240

aaatacaacg ctgtagaaag gaaactagtc aattatgcta aaggtaaacc attagaggct      300

gatttaacgg caaacgagct tgattatgaa aataataaaa taacttctga attgtttcaa      360

tcagctgaag aatatactga ttcattaatg gatcctgcta tattaacttc gttatcttca      420

aatctaaatg cagtcatgtt ttggttagaa cgacactcaa atgacgttgc tgatgcaaac      480

aaaatttata aacgtagact ggatctattt accatagtag catctacaat aaataaatat      540

ggagtaccta gacataatga aaaatataga tatgaatacg aggtgatgaa ggataaaccg      600

tactacttag taacctgggc caactcatct atagaaatgc ttatgtcagt gttttcccat      660

gaagattatt taatagcaaa agagttaata atcttatcat attcaaatag atcaacgtta      720

gcaaaactag tttcatctcc aatgtcgata ttggttgcat taatagatat caatggtacg      780

tttattacaa atgaagagtt agaactcgag ttttcagata aatatgttaa ggcaattgtg      840

cctgatcaaa ttttcgatga attacaggaa atgatcgaca atatgaggaa agttggttta      900

gtagatatac caaaaatgat tcaagaatgg ttaattgatt gttcattaga gaaatttaca      960

ttgatgtcaa aaatttattc ttggtcattt catgttggtt ttagaaaaca aaagatgatt     1020

gatgcagcat tagaccaatt gaaaacagag tacactgaag atgtagataa tgagatgtat     1080

aatgagtata cgatgttaat tagagatgaa atagttaaaa tgctagaagt accagttaaa     1140

catgatgatc atctacttcg cgattcagaa ttagccggat tgttatcaat gtcatcagct     1200

tcaaatggtg aatcaaggca acttaaattt ggtcgtaaaa caatattttc aactaagaaa     1260

aatatgcatg tcatggatga tatcgcacat ggaaaatata ctccgggtgt cattcctcca     1320

gtaaatgtag atagaccaat tccactaggt cgtagagatg ttcctggacg aagaacaaga     1380

attatattca tattaccata tgaatacttt attgcgcagc acgctgtcgt agaaaaaatg     1440

ttatcatacg caaagcatac tagagagtac gcagaatttt attcgcagtc aaatcaattg     1500

ctatcatatg gtgatgttac aagattctta tccaataatt ctatggtatt atacacagac     1560

gtttcacaat gggattcgtc acaacataac acacaaccat ttagaaaagg aataattatg     1620

ggtttagata tgctatccaa tatgactaat gatccaaaag tagtacaaac gctaaattta     1680

tataaacaaa cacaaattaa tctcatggat tcatatgttc aaatacctga cggtaatgta     1740

ataaaaaaga ttcagtatgg tgctgttgct tcaggagaaa aacaaaccaa ggcagctaat     1800

tctatagcta atttggcact cattaaaacg gtattgtcaa gaattgcaaa taaatattct     1860

tttataacca aaataatcag agtcgatggt gatgataatt atgcagtact acaatttaat     1920

accgatgtca ctaaacaaat ggtccaagat gtgtcaaacg atgtgaggta tatatattct     1980

agaatgaatg ctaaagttaa agcactggta tctacagtcg gtatcgaaat agcaaaaaga     2040

tatatagcag gaggaaaaat atttttcaga gctggtataa acttattaaa taatgagaaa     2100

cgtggacaaa gtacacaatg ggatcaagca gctattttat actcaaacta cattgttaac     2160

aaattacgag gatttgagac tgatagagaa tttgtactaa ctaaaattat acaaatgaca     2220

tctatagcta ttactggatc actaaggcta tttccgtcag aacgagtgtt aactactaat     2280

tctacattca aagtatttga ctcagaagat ttcattatag agtatggaac aactgacgat     2340

gaagtatata tacaaagagc atttatgtca ttatctagtc aaaagtcagg aatagctgat     2400

gaaattgctt cttcacaaac atttaaaaat tatgtcaata aattatctga ccaactatta     2460

gtatcaaaaa acgtaattgt atctaaaggt atagctgtaa cagaaaaggc gaaattgaat     2520

tcatatgcac cagtttattt agaaaaacgt cgtgcacaaa tatcagcgct attaactatg     2580

ttgcagaaac cagtgtcatt taaatcaaat aaaattacta ttaatgacat tttgcgtgac     2640

ataaaaccat tttttgtcac ttctgaagct aatttgtcaa ttcaatacag aaaatttatg     2700

ccaacactac ctgataatgt ccaatatgtt atacaatgta taggatcgag gacgtaccag     2760

atagaagata gtgggtcaaa atcatcgatt tcgaagttaa tatcaaaata ttcagtttac     2820

aaaccatcga ttgaagaact atataaagtt atatctttaa gagaacaaga aatacagttg     2880

tatttagttt cattaggagt tccgctagtt gatgcaagca cgtacgtcgg gtcaagaata     2940

tattcgcaag ataaatataa aatattagaa tcttacgtat ataatttatt atcaattaat     3000

tatggatgtt atcaattatt cgattttaat tctccagatt tagagagact tatacgaatt     3060

ccttttaaag gtaagatacc agctgtaaca tttatattac atctttacgc taaacttgaa     3120

ataataaact atgctattaa gaacggagct tggatcagct tgttttgtaa ctatccaaaa     3180

tctgagatga ttaaattatg gaagaaaatg tggaatataa cagcattacg gtctccctat     3240

actagtgcga atttctttca agattag                                         3267


<210>  48
<211>  1088
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapted RV3 VP1

<400>  48

Met Gly Lys Tyr Asn Leu Ile Leu Ser Glu Tyr Leu Ser Phe Val Tyr 
1               5                   10                  15      


Asn Ser Gln Ser Ala Val Gln Ile Pro Ile Tyr Tyr Ser Ser Asn Ser 
            20                  25                  30          


Glu Leu Glu Lys Arg Cys Ile Glu Phe His Ala Lys Cys Val Asp Ser 
        35                  40                  45              


Ser Lys Lys Gly Leu Ser Leu Lys Pro Leu Phe Glu Lys Tyr Lys Asp 
    50                  55                  60                  


Val Ile Asp Asn Ala Thr Leu Leu Ser Leu Leu Ser Tyr Ser Tyr Asp 
65                  70                  75                  80  


Lys Tyr Asn Ala Val Glu Arg Lys Leu Val Asn Tyr Ala Lys Gly Lys 
                85                  90                  95      


Pro Leu Glu Ala Asp Leu Thr Ala Asn Glu Leu Asp Tyr Glu Asn Asn 
            100                 105                 110         


Lys Ile Thr Ser Glu Leu Phe Gln Ser Ala Glu Glu Tyr Thr Asp Ser 
        115                 120                 125             


Leu Met Asp Pro Ala Ile Leu Thr Ser Leu Ser Ser Asn Leu Asn Ala 
    130                 135                 140                 


Val Met Phe Trp Leu Glu Arg His Ser Asn Asp Val Ala Asp Ala Asn 
145                 150                 155                 160 


Lys Ile Tyr Lys Arg Arg Leu Asp Leu Phe Thr Ile Val Ala Ser Thr 
                165                 170                 175     


Ile Asn Lys Tyr Gly Val Pro Arg His Asn Glu Lys Tyr Arg Tyr Glu 
            180                 185                 190         


Tyr Glu Val Met Lys Asp Lys Pro Tyr Tyr Leu Val Thr Trp Ala Asn 
        195                 200                 205             


Ser Ser Ile Glu Met Leu Met Ser Val Phe Ser His Glu Asp Tyr Leu 
    210                 215                 220                 


Ile Ala Lys Glu Leu Ile Ile Leu Ser Tyr Ser Asn Arg Ser Thr Leu 
225                 230                 235                 240 


Ala Lys Leu Val Ser Ser Pro Met Ser Ile Leu Val Ala Leu Ile Asp 
                245                 250                 255     


Ile Asn Gly Thr Phe Ile Thr Asn Glu Glu Leu Glu Leu Glu Phe Ser 
            260                 265                 270         


Asp Lys Tyr Val Lys Ala Ile Val Pro Asp Gln Ile Phe Asp Glu Leu 
        275                 280                 285             


Gln Glu Met Ile Asp Asn Met Arg Lys Val Gly Leu Val Asp Ile Pro 
    290                 295                 300                 


Lys Met Ile Gln Glu Trp Leu Ile Asp Cys Ser Leu Glu Lys Phe Thr 
305                 310                 315                 320 


Leu Met Ser Lys Ile Tyr Ser Trp Ser Phe His Val Gly Phe Arg Lys 
                325                 330                 335     


Gln Lys Met Ile Asp Ala Ala Leu Asp Gln Leu Lys Thr Glu Tyr Thr 
            340                 345                 350         


Glu Asp Val Asp Asn Glu Met Tyr Asn Glu Tyr Thr Met Leu Ile Arg 
        355                 360                 365             


Asp Glu Ile Val Lys Met Leu Glu Val Pro Val Lys His Asp Asp His 
    370                 375                 380                 


Leu Leu Arg Asp Ser Glu Leu Ala Gly Leu Leu Ser Met Ser Ser Ala 
385                 390                 395                 400 


Ser Asn Gly Glu Ser Arg Gln Leu Lys Phe Gly Arg Lys Thr Ile Phe 
                405                 410                 415     


Ser Thr Lys Lys Asn Met His Val Met Asp Asp Ile Ala His Gly Lys 
            420                 425                 430         


Tyr Thr Pro Gly Val Ile Pro Pro Val Asn Val Asp Arg Pro Ile Pro 
        435                 440                 445             


Leu Gly Arg Arg Asp Val Pro Gly Arg Arg Thr Arg Ile Ile Phe Ile 
    450                 455                 460                 


Leu Pro Tyr Glu Tyr Phe Ile Ala Gln His Ala Val Val Glu Lys Met 
465                 470                 475                 480 


Leu Ser Tyr Ala Lys His Thr Arg Glu Tyr Ala Glu Phe Tyr Ser Gln 
                485                 490                 495     


Ser Asn Gln Leu Leu Ser Tyr Gly Asp Val Thr Arg Phe Leu Ser Asn 
            500                 505                 510         


Asn Ser Met Val Leu Tyr Thr Asp Val Ser Gln Trp Asp Ser Ser Gln 
        515                 520                 525             


His Asn Thr Gln Pro Phe Arg Lys Gly Ile Ile Met Gly Leu Asp Met 
    530                 535                 540                 


Leu Ser Asn Met Thr Asn Asp Pro Lys Val Val Gln Thr Leu Asn Leu 
545                 550                 555                 560 


Tyr Lys Gln Thr Gln Ile Asn Leu Met Asp Ser Tyr Val Gln Ile Pro 
                565                 570                 575     


Asp Gly Asn Val Ile Lys Lys Ile Gln Tyr Gly Ala Val Ala Ser Gly 
            580                 585                 590         


Glu Lys Gln Thr Lys Ala Ala Asn Ser Ile Ala Asn Leu Ala Leu Ile 
        595                 600                 605             


Lys Thr Val Leu Ser Arg Ile Ala Asn Lys Tyr Ser Phe Ile Thr Lys 
    610                 615                 620                 


Ile Ile Arg Val Asp Gly Asp Asp Asn Tyr Ala Val Leu Gln Phe Asn 
625                 630                 635                 640 


Thr Asp Val Thr Lys Gln Met Val Gln Asp Val Ser Asn Asp Val Arg 
                645                 650                 655     


Tyr Ile Tyr Ser Arg Met Asn Ala Lys Val Lys Ala Leu Val Ser Thr 
            660                 665                 670         


Val Gly Ile Glu Ile Ala Lys Arg Tyr Ile Ala Gly Gly Lys Ile Phe 
        675                 680                 685             


Phe Arg Ala Gly Ile Asn Leu Leu Asn Asn Glu Lys Arg Gly Gln Ser 
    690                 695                 700                 


Thr Gln Trp Asp Gln Ala Ala Ile Leu Tyr Ser Asn Tyr Ile Val Asn 
705                 710                 715                 720 


Lys Leu Arg Gly Phe Glu Thr Asp Arg Glu Phe Val Leu Thr Lys Ile 
                725                 730                 735     


Ile Gln Met Thr Ser Ile Ala Ile Thr Gly Ser Leu Arg Leu Phe Pro 
            740                 745                 750         


Ser Glu Arg Val Leu Thr Thr Asn Ser Thr Phe Lys Val Phe Asp Ser 
        755                 760                 765             


Glu Asp Phe Ile Ile Glu Tyr Gly Thr Thr Asp Asp Glu Val Tyr Ile 
    770                 775                 780                 


Gln Arg Ala Phe Met Ser Leu Ser Ser Gln Lys Ser Gly Ile Ala Asp 
785                 790                 795                 800 


Glu Ile Ala Ser Ser Gln Thr Phe Lys Asn Tyr Val Asn Lys Leu Ser 
                805                 810                 815     


Asp Gln Leu Leu Val Ser Lys Asn Val Ile Val Ser Lys Gly Ile Ala 
            820                 825                 830         


Val Thr Glu Lys Ala Lys Leu Asn Ser Tyr Ala Pro Val Tyr Leu Glu 
        835                 840                 845             


Lys Arg Arg Ala Gln Ile Ser Ala Leu Leu Thr Met Leu Gln Lys Pro 
    850                 855                 860                 


Val Ser Phe Lys Ser Asn Lys Ile Thr Ile Asn Asp Ile Leu Arg Asp 
865                 870                 875                 880 


Ile Lys Pro Phe Phe Val Thr Ser Glu Ala Asn Leu Ser Ile Gln Tyr 
                885                 890                 895     


Arg Lys Phe Met Pro Thr Leu Pro Asp Asn Val Gln Tyr Val Ile Gln 
            900                 905                 910         


Cys Ile Gly Ser Arg Thr Tyr Gln Ile Glu Asp Ser Gly Ser Lys Ser 
        915                 920                 925             


Ser Ile Ser Lys Leu Ile Ser Lys Tyr Ser Val Tyr Lys Pro Ser Ile 
    930                 935                 940                 


Glu Glu Leu Tyr Lys Val Ile Ser Leu Arg Glu Gln Glu Ile Gln Leu 
945                 950                 955                 960 


Tyr Leu Val Ser Leu Gly Val Pro Leu Val Asp Ala Ser Thr Tyr Val 
                965                 970                 975     


Gly Ser Arg Ile Tyr Ser Gln Asp Lys Tyr Lys Ile Leu Glu Ser Tyr 
            980                 985                 990         


Val Tyr Asn Leu Leu Ser Ile Asn  Tyr Gly Cys Tyr Gln  Leu Phe Asp 
        995                 1000                 1005             


Phe Asn  Ser Pro Asp Leu Glu  Arg Leu Ile Arg Ile  Pro Phe Lys 
    1010                 1015                 1020             


Gly Lys  Ile Pro Ala Val Thr  Phe Ile Leu His Leu  Tyr Ala Lys 
    1025                 1030                 1035             


Leu Glu  Ile Ile Asn Tyr Ala  Ile Lys Asn Gly Ala  Trp Ile Ser 
    1040                 1045                 1050             


Leu Phe  Cys Asn Tyr Pro Lys  Ser Glu Met Ile Lys  Leu Trp Lys 
    1055                 1060                 1065             


Lys Met  Trp Asn Ile Thr Ala  Leu Arg Ser Pro Tyr  Thr Ser Ala 
    1070                 1075                 1080             


Asn Phe  Phe Gln Asp 
    1085             


<210>  49
<211>  3322
<212>  DNA
<213>  artificial

<220>
<223>  Vero-adatped RV3 VP1

<400>  49
tgtaaaacga cggccagtgg ctattaaagc tgtacaatgg ggaagtacaa tctaatcttg       60

tcagaatatt tatcatttgt ttataattca caatctgcag ttcaaatacc aatttattat      120

tcttccaatt cagaattaga aaaaagatgt attgaatttc atgctaaatg tgttgacagt      180

tcaaaaaaag gtctatcatt aaaaccttta ttcgaaaaat ataaagatgt aatagataat      240

gcaactttac tatctctatt atcatattct tatgataaat acaacgctgt agaaaggaaa      300

ctagtcaatt atgctaaagg taaaccatta gaggctgatt taacggcaaa cgagcttgat      360

tatgaaaata ataaaataac ttctgaattg tttcaatcag ctgaagaata tactgattca      420

ttaatggatc ctgctatatt aacttcgtta tcttcaaatc taaatgcagt catgttttgg      480

ttagaacgac actcaaatga cgttgctgat gcaaacaaaa tttataaacg tagactggat      540

ctatttacca tagtagcatc tacaataaat aaatatggag tacctagaca taatgaaaaa      600

tatagatatg aatacgaggt gatgaaggat aaaccgtact acttagtaac ctgggccaac      660

tcatctatag aaatgcttat gtcagtgttt tcccatgaag attatttaat agcaaaagag      720

ttaataatct tatcatattc aaatagatca acgttagcaa aactagtttc atctccaatg      780

tcgatattgg ttgcattaat agatatcaat ggtacgttta ttacaaatga agagttagaa      840

ctcgagtttt cagataaata tgttaaggca attgtgcctg atcaaatttt cgatgaatta      900

caggaaatga tcgacaatat gaggaaagtt ggtttagtag atataccaaa aatgattcaa      960

gaatggttaa ttgattgttc attagagaaa tttacattga tgtcaaaaat ttattcttgg     1020

tcatttcatg ttggttttag aaaacaaaag atgattgatg cagcattaga ccaattgaaa     1080

acagagtaca ctgaagatgt agataatgag atgtataatg agtatacgat gttaattaga     1140

gatgaaatag ttaaaatgct agaagtacca gttaaacatg atgatcatct acttcgcgat     1200

tcagaattag ccggattgtt atcaatgtca tcagcttcaa atggtgaatc aaggcaactt     1260

aaatttggtc gtaaaacaat attttcaact aagaaaaata tgcatgtcat ggatgatatc     1320

gcacatggaa aatatactcc gggtgtcatt cctccagtaa atgtagatag accaattcca     1380

ctaggtcgta gagatgttcc tggacgaaga acaagaatta tattcatatt accatatgaa     1440

tactttattg cgcagcacgc tgtcgtagaa aaaatgttat catacgcaaa gcatactaga     1500

gagtacgcag aattttattc gcagtcaaat caattgctat catatggtga tgttacaaga     1560

ttcttatcca ataattctat ggtattatac acagacgttt cacaatggga ttcgtcacaa     1620

cataacacac aaccatttag aaaaggaata attatgggtt tagatatgct atccaatatg     1680

actaatgatc caaaagtagt acaaacgcta aatttatata aacaaacaca aattaatctc     1740

atggattcat atgttcaaat acctgacggt aatgtaataa aaaagattca gtatggtgct     1800

gttgcttcag gagaaaaaca aaccaaggca gctaattcta tagctaattt ggcactcatt     1860

aaaacggtat tgtcaagaat tgcaaataaa tattctttta taaccaaaat aatcagagtc     1920

gatggtgatg ataattatgc agtactacaa tttaataccg atgtcactaa acaaatggtc     1980

caagatgtgt caaacgatgt gaggtatata tattctagaa tgaatgctaa agttaaagca     2040

ctggtatcta cagtcggtat cgaaatagca aaaagatata tagcaggagg aaaaatattt     2100

ttcagagctg gtataaactt attaaataat gagaaacgtg gacaaagtac acaatgggat     2160

caagcagcta ttttatactc aaactacatt gttaacaaat tacgaggatt tgagactgat     2220

agagaatttg tactaactaa aattatacaa atgacatcta tagctattac tggatcacta     2280

aggctatttc cgtcagaacg agtgttaact actaattcta cattcaaagt atttgactca     2340

gaagatttca ttatagagta tggaacaact gacgatgaag tatatataca aagagcattt     2400

atgtcattat ctagtcaaaa gtcaggaata gctgatgaaa ttgcttcttc acaaacattt     2460

aaaaattatg tcaataaatt atctgaccaa ctattagtat caaaaaacgt aattgtatct     2520

aaaggtatag ctgtaacaga aaaggcgaaa ttgaattcat atgcaccagt ttatttagaa     2580

aaacgtcgtg cacaaatatc agcgctatta actatgttgc agaaaccagt gtcatttaaa     2640

tcaaataaaa ttactattaa tgacattttg cgtgacataa aaccattttt tttcacttct     2700

gaagctaatt tgtcaattca atacagaaaa tttatgccaa cactacctga taatgtccaa     2760

tatgttatac aatgtatagg atcgaggacg taccagatag aagatagtgg gtcaaaatca     2820

tcgatttcga agttaatatc aaaatattca gtttacaaac catcgattga agaactatat     2880

aaagttatat ctttaagaga acaagaaata cagttgtatt tagtttcatt aggagttccg     2940

ctagttgatg caagcacgta cgtcgggtca agaatatatt cgcaagataa atataaaata     3000

ttagaatctt acgtatataa tttattatca attaattatg gatgttatca attattcgat     3060

tttaattctc cagatttaga gagacttata cgaattcctt ttaaaggtaa gataccagct     3120

gtaacattta tattacatct ttacgctaaa cttgaaataa taaactatgc tattaagaac     3180

ggagcttgga tcagcttgtt ttgtaactat ccaaaatctg agatgattaa attatggaag     3240

aaaatgtgga atataacagc attacggtct ccctatacta gtgcgaattt ctttcaagat     3300

tagagcggct taggatgtga cc                                              3322


<210>  50
<211>  1088
<212>  PRT
<213>  artificial

<220>
<223>  Vero-adapted RV3 VP1

<400>  50

Met Gly Lys Tyr Asn Leu Ile Leu Ser Glu Tyr Leu Ser Phe Val Tyr 
1               5                   10                  15      


Asn Ser Gln Ser Ala Val Gln Ile Pro Ile Tyr Tyr Ser Ser Asn Ser 
            20                  25                  30          


Glu Leu Glu Lys Arg Cys Ile Glu Phe His Ala Lys Cys Val Asp Ser 
        35                  40                  45              


Ser Lys Lys Gly Leu Ser Leu Lys Pro Leu Phe Glu Lys Tyr Lys Asp 
    50                  55                  60                  


Val Ile Asp Asn Ala Thr Leu Leu Ser Leu Leu Ser Tyr Ser Tyr Asp 
65                  70                  75                  80  


Lys Tyr Asn Ala Val Glu Arg Lys Leu Val Asn Tyr Ala Lys Gly Lys 
                85                  90                  95      


Pro Leu Glu Ala Asp Leu Thr Ala Asn Glu Leu Asp Tyr Glu Asn Asn 
            100                 105                 110         


Lys Ile Thr Ser Glu Leu Phe Gln Ser Ala Glu Glu Tyr Thr Asp Ser 
        115                 120                 125             


Leu Met Asp Pro Ala Ile Leu Thr Ser Leu Ser Ser Asn Leu Asn Ala 
    130                 135                 140                 


Val Met Phe Trp Leu Glu Arg His Ser Asn Asp Val Ala Asp Ala Asn 
145                 150                 155                 160 


Lys Ile Tyr Lys Arg Arg Leu Asp Leu Phe Thr Ile Val Ala Ser Thr 
                165                 170                 175     


Ile Asn Lys Tyr Gly Val Pro Arg His Asn Glu Lys Tyr Arg Tyr Glu 
            180                 185                 190         


Tyr Glu Val Met Lys Asp Lys Pro Tyr Tyr Leu Val Thr Trp Ala Asn 
        195                 200                 205             


Ser Ser Ile Glu Met Leu Met Ser Val Phe Ser His Glu Asp Tyr Leu 
    210                 215                 220                 


Ile Ala Lys Glu Leu Ile Ile Leu Ser Tyr Ser Asn Arg Ser Thr Leu 
225                 230                 235                 240 


Ala Lys Leu Val Ser Ser Pro Met Ser Ile Leu Val Ala Leu Ile Asp 
                245                 250                 255     


Ile Asn Gly Thr Phe Ile Thr Asn Glu Glu Leu Glu Leu Glu Phe Ser 
            260                 265                 270         


Asp Lys Tyr Val Lys Ala Ile Val Pro Asp Gln Ile Phe Asp Glu Leu 
        275                 280                 285             


Gln Glu Met Ile Asp Asn Met Arg Lys Val Gly Leu Val Asp Ile Pro 
    290                 295                 300                 


Lys Met Ile Gln Glu Trp Leu Ile Asp Cys Ser Leu Glu Lys Phe Thr 
305                 310                 315                 320 


Leu Met Ser Lys Ile Tyr Ser Trp Ser Phe His Val Gly Phe Arg Lys 
                325                 330                 335     


Gln Lys Met Ile Asp Ala Ala Leu Asp Gln Leu Lys Thr Glu Tyr Thr 
            340                 345                 350         


Glu Asp Val Asp Asn Glu Met Tyr Asn Glu Tyr Thr Met Leu Ile Arg 
        355                 360                 365             


Asp Glu Ile Val Lys Met Leu Glu Val Pro Val Lys His Asp Asp His 
    370                 375                 380                 


Leu Leu Arg Asp Ser Glu Leu Ala Gly Leu Leu Ser Met Ser Ser Ala 
385                 390                 395                 400 


Ser Asn Gly Glu Ser Arg Gln Leu Lys Phe Gly Arg Lys Thr Ile Phe 
                405                 410                 415     


Ser Thr Lys Lys Asn Met His Val Met Asp Asp Ile Ala His Gly Lys 
            420                 425                 430         


Tyr Thr Pro Gly Val Ile Pro Pro Val Asn Val Asp Arg Pro Ile Pro 
        435                 440                 445             


Leu Gly Arg Arg Asp Val Pro Gly Arg Arg Thr Arg Ile Ile Phe Ile 
    450                 455                 460                 


Leu Pro Tyr Glu Tyr Phe Ile Ala Gln His Ala Val Val Glu Lys Met 
465                 470                 475                 480 


Leu Ser Tyr Ala Lys His Thr Arg Glu Tyr Ala Glu Phe Tyr Ser Gln 
                485                 490                 495     


Ser Asn Gln Leu Leu Ser Tyr Gly Asp Val Thr Arg Phe Leu Ser Asn 
            500                 505                 510         


Asn Ser Met Val Leu Tyr Thr Asp Val Ser Gln Trp Asp Ser Ser Gln 
        515                 520                 525             


His Asn Thr Gln Pro Phe Arg Lys Gly Ile Ile Met Gly Leu Asp Met 
    530                 535                 540                 


Leu Ser Asn Met Thr Asn Asp Pro Lys Val Val Gln Thr Leu Asn Leu 
545                 550                 555                 560 


Tyr Lys Gln Thr Gln Ile Asn Leu Met Asp Ser Tyr Val Gln Ile Pro 
                565                 570                 575     


Asp Gly Asn Val Ile Lys Lys Ile Gln Tyr Gly Ala Val Ala Ser Gly 
            580                 585                 590         


Glu Lys Gln Thr Lys Ala Ala Asn Ser Ile Ala Asn Leu Ala Leu Ile 
        595                 600                 605             


Lys Thr Val Leu Ser Arg Ile Ala Asn Lys Tyr Ser Phe Ile Thr Lys 
    610                 615                 620                 


Ile Ile Arg Val Asp Gly Asp Asp Asn Tyr Ala Val Leu Gln Phe Asn 
625                 630                 635                 640 


Thr Asp Val Thr Lys Gln Met Val Gln Asp Val Ser Asn Asp Val Arg 
                645                 650                 655     


Tyr Ile Tyr Ser Arg Met Asn Ala Lys Val Lys Ala Leu Val Ser Thr 
            660                 665                 670         


Val Gly Ile Glu Ile Ala Lys Arg Tyr Ile Ala Gly Gly Lys Ile Phe 
        675                 680                 685             


Phe Arg Ala Gly Ile Asn Leu Leu Asn Asn Glu Lys Arg Gly Gln Ser 
    690                 695                 700                 


Thr Gln Trp Asp Gln Ala Ala Ile Leu Tyr Ser Asn Tyr Ile Val Asn 
705                 710                 715                 720 


Lys Leu Arg Gly Phe Glu Thr Asp Arg Glu Phe Val Leu Thr Lys Ile 
                725                 730                 735     


Ile Gln Met Thr Ser Ile Ala Ile Thr Gly Ser Leu Arg Leu Phe Pro 
            740                 745                 750         


Ser Glu Arg Val Leu Thr Thr Asn Ser Thr Phe Lys Val Phe Asp Ser 
        755                 760                 765             


Glu Asp Phe Ile Ile Glu Tyr Gly Thr Thr Asp Asp Glu Val Tyr Ile 
    770                 775                 780                 


Gln Arg Ala Phe Met Ser Leu Ser Ser Gln Lys Ser Gly Ile Ala Asp 
785                 790                 795                 800 


Glu Ile Ala Ser Ser Gln Thr Phe Lys Asn Tyr Val Asn Lys Leu Ser 
                805                 810                 815     


Asp Gln Leu Leu Val Ser Lys Asn Val Ile Val Ser Lys Gly Ile Ala 
            820                 825                 830         


Val Thr Glu Lys Ala Lys Leu Asn Ser Tyr Ala Pro Val Tyr Leu Glu 
        835                 840                 845             


Lys Arg Arg Ala Gln Ile Ser Ala Leu Leu Thr Met Leu Gln Lys Pro 
    850                 855                 860                 


Val Ser Phe Lys Ser Asn Lys Ile Thr Ile Asn Asp Ile Leu Arg Asp 
865                 870                 875                 880 


Ile Lys Pro Phe Phe Phe Thr Ser Glu Ala Asn Leu Ser Ile Gln Tyr 
                885                 890                 895     


Arg Lys Phe Met Pro Thr Leu Pro Asp Asn Val Gln Tyr Val Ile Gln 
            900                 905                 910         


Cys Ile Gly Ser Arg Thr Tyr Gln Ile Glu Asp Ser Gly Ser Lys Ser 
        915                 920                 925             


Ser Ile Ser Lys Leu Ile Ser Lys Tyr Ser Val Tyr Lys Pro Ser Ile 
    930                 935                 940                 


Glu Glu Leu Tyr Lys Val Ile Ser Leu Arg Glu Gln Glu Ile Gln Leu 
945                 950                 955                 960 


Tyr Leu Val Ser Leu Gly Val Pro Leu Val Asp Ala Ser Thr Tyr Val 
                965                 970                 975     


Gly Ser Arg Ile Tyr Ser Gln Asp Lys Tyr Lys Ile Leu Glu Ser Tyr 
            980                 985                 990         


Val Tyr Asn Leu Leu Ser Ile Asn  Tyr Gly Cys Tyr Gln  Leu Phe Asp 
        995                 1000                 1005             


Phe Asn  Ser Pro Asp Leu Glu  Arg Leu Ile Arg Ile  Pro Phe Lys 
    1010                 1015                 1020             


Gly Lys  Ile Pro Ala Val Thr  Phe Ile Leu His Leu  Tyr Ala Lys 
    1025                 1030                 1035             


Leu Glu  Ile Ile Asn Tyr Ala  Ile Lys Asn Gly Ala  Trp Ile Ser 
    1040                 1045                 1050             


Leu Phe  Cys Asn Tyr Pro Lys  Ser Glu Met Ile Lys  Leu Trp Lys 
    1055                 1060                 1065             


Lys Met  Trp Asn Ile Thr Ala  Leu Arg Ser Pro Tyr  Thr Ser Ala 
    1070                 1075                 1080             


Asn Phe  Phe Gln Asp 
    1085             


<210>  51
<211>  2673
<212>  DNA
<213>  artificial

<220>
<223>  MA104-adapted RV3 VP2

<400>  51
atggcgtaca ggaagcgcgg agttaaacgt gaaaacttac cacaacaaaa tgaacgtctg       60

caagaaaaag aaactgaaaa taatacagac gtaaccatgg aaaataaaaa taacaataga      120

aggcagcaat tatctgacaa agtgttatca caaaaagagg aaataataac tgatgtacaa      180

gatgacatta aaatagctga tgaggttaaa aaatcatcaa aagaagagtc aaaacagtta      240

cttgaaatat taaaaacgaa agaagatcat cagaaagaag tacagtacga aattctacaa      300

aaaacaatac cgacttttga accaaaagaa tcaattttga aaaaattaga agatataaga      360

ccagaacaag ctaagaagca aatgaaattg tttagaatat ttgaaccaag acaattacca      420

atctatcgag caaatggtga gaaagagtta aggaatagat ggtattggaa attgaaaaag      480

gatacactgc cggacggaga ttatgacgta cgagagtatt ttttaaattt atatgatcaa      540

atactgatag aaatgccaga ttatttatta ctaaaagata tggctgtaga aaataaaaac      600

tctagagatg ctggtaaagt tgtagattct gagactgcaa gtatttgtga tgctatattt      660

caagatgagg agacagaggg agttattaga agattcatcg cagatatgag acaacaagtt      720

caagctgata gaaatattgt caattatcca tcaattttgc atccgattga tcacgcattt      780

aatgaatact ttttgaatca tcaattagtt gaaccattga ataacgaaat tatttttaat      840

tatataccag aaagaataag gaatgatgtt aactatattt tgaatatgga tatgaatttg      900

ccatcaacag cgcgatatat tagaccaaat ctattgcaag atagactaaa tttacatgat      960

aattttgaat cattatggga cacgataact acatcaaatt acatattagc aagatcagtc     1020

gtgcctgatt tgaaggaaaa agaattagtt tcaactgaag ctcagatcca gaaaatgtct     1080

caagatttgc agcttgaagc tttaacaata caatctgaaa cgcagtttct ggccggtata     1140

aattcacaag cagcgaatga ttgttttaaa acactgatag cagctatgtt aagccaacgt     1200

acaatgtcat tagattttgt aactacgaat tatatgtcac ttatatctgg catgtggcta     1260

ttgactgtta taccaaatga tatgtttctt cgtgagtcgc tagtcgcatg cgaattggct     1320

ataataaata ctatagttta tccagcattt ggaatgcaaa gaatgcatta tagaaatggc     1380

gatcctcaga ctccatttca aatagcagaa caacagatac aaaattttca agtagctaat     1440

tggttacatt ttattaacaa taatagattt aggcaagttg ttattgatgg agtgttaaat     1500

caaacactta atgacaacat taggaatgga caagttatta atcaattaat ggaagcatta     1560

atgcagttat ctagacaaca atttccgacc atgccagttg attataaaag atcaatccag     1620

agaggaatat tgttattatc taacagatta ggtcagttgg ttgatttaac aagattatta     1680

tcatacaatt atgaaactct aatggcttgt ataactatga acatgcaaca tgttcaaact     1740

ctcactaccg aaaaattaca attaacttct gtcacatctt tatgtatgtt aattggaaat     1800

accacagtaa ttccaggtcc acaaacacta tttcactatt ataacgtaaa tgtaaatttt     1860

cattcaaatt ataacgaacg aattaatgat gctgtggcta ttattacggc tgctaataga     1920

ttaaacttat atcagaaaaa aatgaaatca atagttgagg attttttgaa aagattgcaa     1980

atttttgatg taccacgagt gccagatgac caaacgtaca ggttgagaga cagacttaga     2040

ttattgccag ttgaaagacg aagacttgat atatttaact taatattaat gaatatggag     2100

cagatcgaac gagcttcaga caaaattgct caaggagtaa taattgctta cagagatatg     2160

cagctagaaa gagatgagat gtatgggttt gttaacatcg ctaggaacct cgatggatat     2220

caacaaatca atttggaaga gttgatgaga actggggact atggtcaaat tactaatatg     2280

ctattaaaca accagcctgt agctttagta ggagcattac catttgtgac agattcatca     2340

gttatatcgc tcattgcaaa attggatgcc acagtttttg ctcaaatagt taaacttaga     2400

aaagtggaca ctttaaaacc aatattgtat aaaataaatt ctgattctaa tgatttctat     2460

ttagttgcaa attatgattg gataccaact tcaaccacaa aagtttataa gcaagtacca     2520

caaccttttg atttcagagc gtcaatgcat atgttaacgt ctaatttaac ttttactgtt     2580

tattccgatt tgctatcttt cgtttctgca gacacggttg aacctattaa cgcaattgct     2640

tttgacaata tgcgcattat gaacgaactg taa                                  2673


<210>  52
<211>  890
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapted RV3 VP2

<400>  52

Met Ala Tyr Arg Lys Arg Gly Val Lys Arg Glu Asn Leu Pro Gln Gln 
1               5                   10                  15      


Asn Glu Arg Leu Gln Glu Lys Glu Thr Glu Asn Asn Thr Asp Val Thr 
            20                  25                  30          


Met Glu Asn Lys Asn Asn Asn Arg Arg Gln Gln Leu Ser Asp Lys Val 
        35                  40                  45              


Leu Ser Gln Lys Glu Glu Ile Ile Thr Asp Val Gln Asp Asp Ile Lys 
    50                  55                  60                  


Ile Ala Asp Glu Val Lys Lys Ser Ser Lys Glu Glu Ser Lys Gln Leu 
65                  70                  75                  80  


Leu Glu Ile Leu Lys Thr Lys Glu Asp His Gln Lys Glu Val Gln Tyr 
                85                  90                  95      


Glu Ile Leu Gln Lys Thr Ile Pro Thr Phe Glu Pro Lys Glu Ser Ile 
            100                 105                 110         


Leu Lys Lys Leu Glu Asp Ile Arg Pro Glu Gln Ala Lys Lys Gln Met 
        115                 120                 125             


Lys Leu Phe Arg Ile Phe Glu Pro Arg Gln Leu Pro Ile Tyr Arg Ala 
    130                 135                 140                 


Asn Gly Glu Lys Glu Leu Arg Asn Arg Trp Tyr Trp Lys Leu Lys Lys 
145                 150                 155                 160 


Asp Thr Leu Pro Asp Gly Asp Tyr Asp Val Arg Glu Tyr Phe Leu Asn 
                165                 170                 175     


Leu Tyr Asp Gln Ile Leu Ile Glu Met Pro Asp Tyr Leu Leu Leu Lys 
            180                 185                 190         


Asp Met Ala Val Glu Asn Lys Asn Ser Arg Asp Ala Gly Lys Val Val 
        195                 200                 205             


Asp Ser Glu Thr Ala Ser Ile Cys Asp Ala Ile Phe Gln Asp Glu Glu 
    210                 215                 220                 


Thr Glu Gly Val Ile Arg Arg Phe Ile Ala Asp Met Arg Gln Gln Val 
225                 230                 235                 240 


Gln Ala Asp Arg Asn Ile Val Asn Tyr Pro Ser Ile Leu His Pro Ile 
                245                 250                 255     


Asp His Ala Phe Asn Glu Tyr Phe Leu Asn His Gln Leu Val Glu Pro 
            260                 265                 270         


Leu Asn Asn Glu Ile Ile Phe Asn Tyr Ile Pro Glu Arg Ile Arg Asn 
        275                 280                 285             


Asp Val Asn Tyr Ile Leu Asn Met Asp Met Asn Leu Pro Ser Thr Ala 
    290                 295                 300                 


Arg Tyr Ile Arg Pro Asn Leu Leu Gln Asp Arg Leu Asn Leu His Asp 
305                 310                 315                 320 


Asn Phe Glu Ser Leu Trp Asp Thr Ile Thr Thr Ser Asn Tyr Ile Leu 
                325                 330                 335     


Ala Arg Ser Val Val Pro Asp Leu Lys Glu Lys Glu Leu Val Ser Thr 
            340                 345                 350         


Glu Ala Gln Ile Gln Lys Met Ser Gln Asp Leu Gln Leu Glu Ala Leu 
        355                 360                 365             


Thr Ile Gln Ser Glu Thr Gln Phe Leu Ala Gly Ile Asn Ser Gln Ala 
    370                 375                 380                 


Ala Asn Asp Cys Phe Lys Thr Leu Ile Ala Ala Met Leu Ser Gln Arg 
385                 390                 395                 400 


Thr Met Ser Leu Asp Phe Val Thr Thr Asn Tyr Met Ser Leu Ile Ser 
                405                 410                 415     


Gly Met Trp Leu Leu Thr Val Ile Pro Asn Asp Met Phe Leu Arg Glu 
            420                 425                 430         


Ser Leu Val Ala Cys Glu Leu Ala Ile Ile Asn Thr Ile Val Tyr Pro 
        435                 440                 445             


Ala Phe Gly Met Gln Arg Met His Tyr Arg Asn Gly Asp Pro Gln Thr 
    450                 455                 460                 


Pro Phe Gln Ile Ala Glu Gln Gln Ile Gln Asn Phe Gln Val Ala Asn 
465                 470                 475                 480 


Trp Leu His Phe Ile Asn Asn Asn Arg Phe Arg Gln Val Val Ile Asp 
                485                 490                 495     


Gly Val Leu Asn Gln Thr Leu Asn Asp Asn Ile Arg Asn Gly Gln Val 
            500                 505                 510         


Ile Asn Gln Leu Met Glu Ala Leu Met Gln Leu Ser Arg Gln Gln Phe 
        515                 520                 525             


Pro Thr Met Pro Val Asp Tyr Lys Arg Ser Ile Gln Arg Gly Ile Leu 
    530                 535                 540                 


Leu Leu Ser Asn Arg Leu Gly Gln Leu Val Asp Leu Thr Arg Leu Leu 
545                 550                 555                 560 


Ser Tyr Asn Tyr Glu Thr Leu Met Ala Cys Ile Thr Met Asn Met Gln 
                565                 570                 575     


His Val Gln Thr Leu Thr Thr Glu Lys Leu Gln Leu Thr Ser Val Thr 
            580                 585                 590         


Ser Leu Cys Met Leu Ile Gly Asn Thr Thr Val Ile Pro Gly Pro Gln 
        595                 600                 605             


Thr Leu Phe His Tyr Tyr Asn Val Asn Val Asn Phe His Ser Asn Tyr 
    610                 615                 620                 


Asn Glu Arg Ile Asn Asp Ala Val Ala Ile Ile Thr Ala Ala Asn Arg 
625                 630                 635                 640 


Leu Asn Leu Tyr Gln Lys Lys Met Lys Ser Ile Val Glu Asp Phe Leu 
                645                 650                 655     


Lys Arg Leu Gln Ile Phe Asp Val Pro Arg Val Pro Asp Asp Gln Thr 
            660                 665                 670         


Tyr Arg Leu Arg Asp Arg Leu Arg Leu Leu Pro Val Glu Arg Arg Arg 
        675                 680                 685             


Leu Asp Ile Phe Asn Leu Ile Leu Met Asn Met Glu Gln Ile Glu Arg 
    690                 695                 700                 


Ala Ser Asp Lys Ile Ala Gln Gly Val Ile Ile Ala Tyr Arg Asp Met 
705                 710                 715                 720 


Gln Leu Glu Arg Asp Glu Met Tyr Gly Phe Val Asn Ile Ala Arg Asn 
                725                 730                 735     


Leu Asp Gly Tyr Gln Gln Ile Asn Leu Glu Glu Leu Met Arg Thr Gly 
            740                 745                 750         


Asp Tyr Gly Gln Ile Thr Asn Met Leu Leu Asn Asn Gln Pro Val Ala 
        755                 760                 765             


Leu Val Gly Ala Leu Pro Phe Val Thr Asp Ser Ser Val Ile Ser Leu 
    770                 775                 780                 


Ile Ala Lys Leu Asp Ala Thr Val Phe Ala Gln Ile Val Lys Leu Arg 
785                 790                 795                 800 


Lys Val Asp Thr Leu Lys Pro Ile Leu Tyr Lys Ile Asn Ser Asp Ser 
                805                 810                 815     


Asn Asp Phe Tyr Leu Val Ala Asn Tyr Asp Trp Ile Pro Thr Ser Thr 
            820                 825                 830         


Thr Lys Val Tyr Lys Gln Val Pro Gln Pro Phe Asp Phe Arg Ala Ser 
        835                 840                 845             


Met His Met Leu Thr Ser Asn Leu Thr Phe Thr Val Tyr Ser Asp Leu 
    850                 855                 860                 


Leu Ser Phe Val Ser Ala Asp Thr Val Glu Pro Ile Asn Ala Ile Ala 
865                 870                 875                 880 


Phe Asp Asn Met Arg Ile Met Asn Glu Leu 
                885                 890 


<210>  53
<211>  2717
<212>  DNA
<213>  artificial

<220>
<223>  Vero-adapted RV3 VP2

<400>  53
ggctattaaa ggttcaatgg cgtacaggaa gcgcggagtt aaacgtgaaa acttaccaca       60

acaaaatgaa cgtctgcaag aaaaagaaac tgaaaataat acagacgtaa ccatggaaaa      120

taaaaataac aatagaaggc agcaattatc tgacaaagtg ttatcacaaa aagaggaaat      180

aataactgat gtacaagatg acattaaaat agctgatgag gttaaaaaat catcaaaaga      240

agagtcaaaa cagttacttg aaatattaaa aacgaaagaa gatcatcaga aagaagtaca      300

gtacgaaatt ctacaaaaaa caataccgac ttttgaacca aaagaatcaa ttttgaaaaa      360

attagaagat ataagaccag aacaagctaa gaagcaaatg aaattgttta gaatatttga      420

accaagacaa ttaccaatct atcgagcaaa tggtgagaaa gagttaagga atagatggta      480

ttggaaattg aaaaaggata cactgccgga cggagattat gacgtacgag agtatttttt      540

aaatttatat gatcaaatac tgatagaaat gccagattat ttattactaa aagatatggc      600

tgtagaaaat aaaaactcta gagatgctgg taaagttgta gattctgaga ctgcaagtat      660

ttgtgatgct atatttcaag atgaggagac agagggagtt attagaagat tcatcgcaga      720

tatgagacaa caagttcaag ctgatagaaa tattgtcaat tatccatcaa ttttgcatcc      780

gattgatcac gcatttaatg aatacttttt gaatcatcaa ttagttgaac cattgaataa      840

cgaaattatt tttaattata taccagaaag aataaggaat gatgttaact atattttgaa      900

tatggatatg aatttgccat caacagcgcg atatattaga ccaaatctat tgcaagatag      960

actaaattta catgataatt ttgaatcatt atgggacacg ataactacat caaattacat     1020

attagcaaga tcagtcgtgc ctgatttgaa ggaaaaagaa ttagtttcaa ctgaagctca     1080

gatccagaaa atgtctcaag atttgcagct tgaagcttta acaatacaat ctgaaacgca     1140

gtttctggcc ggtataaatt cacaagcagc gaatgattgt tttaaaacac tgatagcagc     1200

tatgttaagc caacgtacaa tgtcattaga ttttgtaact acgaattata tgtcacttat     1260

atctggcatg tggctattga ctgttatacc aaatgatatg tttcttcgtg agtcgctagt     1320

cgcatgcgaa ttggctataa taaatactat agtttatcca gcatttggaa tgcaaagaat     1380

gcattataga aatggcgatc ctcagactcc atttcaaata gcagaacaac agatacaaaa     1440

ttttcaagta gctaattggt tacattttat taacaataat agatttaggc aagttgttat     1500

tgatggagtg ttaaatcaaa cacttaatga caacattagg aatggacaag ttattaatca     1560

attaatggaa gcattaatgc agttatctag acaacaattt ccgaccatgc cagttgatta     1620

taaaagatca atccagagag gaatattgtt attatctaac agattaggtc agttggttga     1680

tttaacaaga ttattatcat acaattatga aactctaatg gcttgtataa ctatgaacat     1740

gcaacatgtt caaactctca ctaccgaaaa attacaatta acttctgtca catctttatg     1800

tatgttaatt ggaaatacca cagtaattcc aggtccacaa acactatttc actattataa     1860

cgtaaatgta aattttcatt caaattataa cgaacgaatt aatgatgctg tggctattat     1920

tacggctgct aatagattaa acttatatca gaaaaaaatg aaatcaatag ttgaggattt     1980

tttgaaaaga ttgcaaattt ttgatgtacc acgagtgcca gatgaccaaa cgtacaggtt     2040

gagagacaga cttagattat tgccagttga aagacgaaga cttgatatat ttaacttaat     2100

attaatgaat atggagcaga tcgaacgagc ttcagacaaa attgctcaag gagtaataat     2160

tgcttacaga gatatgcagc tagaaagaga tgagatgtat gggtttgtta acatcgctag     2220

gaacctcgat ggatatcaac aaatcaattt ggaagagttg atgagaactg gggactatgg     2280

tcaaattact aatatgctat taaacaacca gcctgtagct ttagtaggag cattaccatt     2340

tgtgacagat tcatcagtta tatcgctcat tgcaaaattg gatgccacag tttttgctca     2400

aatagttaaa cttagaaaag tggacacttt aaaaccaata ttgtataaaa taaattctga     2460

ttctaatgat ttctatttag ttgcaaatta tgattggata ccaacttcaa ccacaaaagt     2520

ttataagcaa gtaccacaac cttttgattt cagagcgtca atgcatatgt taacgtctaa     2580

tttaactttt actgtttatt ccgatttgct atctttcgtt tctgcagaca cggttgaacc     2640

tattaacgca attgcttttg acaatatgcg cattatgaac gaactgtaaa cgccaacccc     2700

actgtggaga tatgacc                                                    2717


<210>  54
<211>  890
<212>  PRT
<213>  artificial

<220>
<223>  Vero-adapated RV3 VP2

<400>  54

Met Ala Tyr Arg Lys Arg Gly Val Lys Arg Glu Asn Leu Pro Gln Gln 
1               5                   10                  15      


Asn Glu Arg Leu Gln Glu Lys Glu Thr Glu Asn Asn Thr Asp Val Thr 
            20                  25                  30          


Met Glu Asn Lys Asn Asn Asn Arg Arg Gln Gln Leu Ser Asp Lys Val 
        35                  40                  45              


Leu Ser Gln Lys Glu Glu Ile Ile Thr Asp Val Gln Asp Asp Ile Lys 
    50                  55                  60                  


Ile Ala Asp Glu Val Lys Lys Ser Ser Lys Glu Glu Ser Lys Gln Leu 
65                  70                  75                  80  


Leu Glu Ile Leu Lys Thr Lys Glu Asp His Gln Lys Glu Val Gln Tyr 
                85                  90                  95      


Glu Ile Leu Gln Lys Thr Ile Pro Thr Phe Glu Pro Lys Glu Ser Ile 
            100                 105                 110         


Leu Lys Lys Leu Glu Asp Ile Arg Pro Glu Gln Ala Lys Lys Gln Met 
        115                 120                 125             


Lys Leu Phe Arg Ile Phe Glu Pro Arg Gln Leu Pro Ile Tyr Arg Ala 
    130                 135                 140                 


Asn Gly Glu Lys Glu Leu Arg Asn Arg Trp Tyr Trp Lys Leu Lys Lys 
145                 150                 155                 160 


Asp Thr Leu Pro Asp Gly Asp Tyr Asp Val Arg Glu Tyr Phe Leu Asn 
                165                 170                 175     


Leu Tyr Asp Gln Ile Leu Ile Glu Met Pro Asp Tyr Leu Leu Leu Lys 
            180                 185                 190         


Asp Met Ala Val Glu Asn Lys Asn Ser Arg Asp Ala Gly Lys Val Val 
        195                 200                 205             


Asp Ser Glu Thr Ala Ser Ile Cys Asp Ala Ile Phe Gln Asp Glu Glu 
    210                 215                 220                 


Thr Glu Gly Val Ile Arg Arg Phe Ile Ala Asp Met Arg Gln Gln Val 
225                 230                 235                 240 


Gln Ala Asp Arg Asn Ile Val Asn Tyr Pro Ser Ile Leu His Pro Ile 
                245                 250                 255     


Asp His Ala Phe Asn Glu Tyr Phe Leu Asn His Gln Leu Val Glu Pro 
            260                 265                 270         


Leu Asn Asn Glu Ile Ile Phe Asn Tyr Ile Pro Glu Arg Ile Arg Asn 
        275                 280                 285             


Asp Val Asn Tyr Ile Leu Asn Met Asp Met Asn Leu Pro Ser Thr Ala 
    290                 295                 300                 


Arg Tyr Ile Arg Pro Asn Leu Leu Gln Asp Arg Leu Asn Leu His Asp 
305                 310                 315                 320 


Asn Phe Glu Ser Leu Trp Asp Thr Ile Thr Thr Ser Asn Tyr Ile Leu 
                325                 330                 335     


Ala Arg Ser Val Val Pro Asp Leu Lys Glu Lys Glu Leu Val Ser Thr 
            340                 345                 350         


Glu Ala Gln Ile Gln Lys Met Ser Gln Asp Leu Gln Leu Glu Ala Leu 
        355                 360                 365             


Thr Ile Gln Ser Glu Thr Gln Phe Leu Ala Gly Ile Asn Ser Gln Ala 
    370                 375                 380                 


Ala Asn Asp Cys Phe Lys Thr Leu Ile Ala Ala Met Leu Ser Gln Arg 
385                 390                 395                 400 


Thr Met Ser Leu Asp Phe Val Thr Thr Asn Tyr Met Ser Leu Ile Ser 
                405                 410                 415     


Gly Met Trp Leu Leu Thr Val Ile Pro Asn Asp Met Phe Leu Arg Glu 
            420                 425                 430         


Ser Leu Val Ala Cys Glu Leu Ala Ile Ile Asn Thr Ile Val Tyr Pro 
        435                 440                 445             


Ala Phe Gly Met Gln Arg Met His Tyr Arg Asn Gly Asp Pro Gln Thr 
    450                 455                 460                 


Pro Phe Gln Ile Ala Glu Gln Gln Ile Gln Asn Phe Gln Val Ala Asn 
465                 470                 475                 480 


Trp Leu His Phe Ile Asn Asn Asn Arg Phe Arg Gln Val Val Ile Asp 
                485                 490                 495     


Gly Val Leu Asn Gln Thr Leu Asn Asp Asn Ile Arg Asn Gly Gln Val 
            500                 505                 510         


Ile Asn Gln Leu Met Glu Ala Leu Met Gln Leu Ser Arg Gln Gln Phe 
        515                 520                 525             


Pro Thr Met Pro Val Asp Tyr Lys Arg Ser Ile Gln Arg Gly Ile Leu 
    530                 535                 540                 


Leu Leu Ser Asn Arg Leu Gly Gln Leu Val Asp Leu Thr Arg Leu Leu 
545                 550                 555                 560 


Ser Tyr Asn Tyr Glu Thr Leu Met Ala Cys Ile Thr Met Asn Met Gln 
                565                 570                 575     


His Val Gln Thr Leu Thr Thr Glu Lys Leu Gln Leu Thr Ser Val Thr 
            580                 585                 590         


Ser Leu Cys Met Leu Ile Gly Asn Thr Thr Val Ile Pro Gly Pro Gln 
        595                 600                 605             


Thr Leu Phe His Tyr Tyr Asn Val Asn Val Asn Phe His Ser Asn Tyr 
    610                 615                 620                 


Asn Glu Arg Ile Asn Asp Ala Val Ala Ile Ile Thr Ala Ala Asn Arg 
625                 630                 635                 640 


Leu Asn Leu Tyr Gln Lys Lys Met Lys Ser Ile Val Glu Asp Phe Leu 
                645                 650                 655     


Lys Arg Leu Gln Ile Phe Asp Val Pro Arg Val Pro Asp Asp Gln Thr 
            660                 665                 670         


Tyr Arg Leu Arg Asp Arg Leu Arg Leu Leu Pro Val Glu Arg Arg Arg 
        675                 680                 685             


Leu Asp Ile Phe Asn Leu Ile Leu Met Asn Met Glu Gln Ile Glu Arg 
    690                 695                 700                 


Ala Ser Asp Lys Ile Ala Gln Gly Val Ile Ile Ala Tyr Arg Asp Met 
705                 710                 715                 720 


Gln Leu Glu Arg Asp Glu Met Tyr Gly Phe Val Asn Ile Ala Arg Asn 
                725                 730                 735     


Leu Asp Gly Tyr Gln Gln Ile Asn Leu Glu Glu Leu Met Arg Thr Gly 
            740                 745                 750         


Asp Tyr Gly Gln Ile Thr Asn Met Leu Leu Asn Asn Gln Pro Val Ala 
        755                 760                 765             


Leu Val Gly Ala Leu Pro Phe Val Thr Asp Ser Ser Val Ile Ser Leu 
    770                 775                 780                 


Ile Ala Lys Leu Asp Ala Thr Val Phe Ala Gln Ile Val Lys Leu Arg 
785                 790                 795                 800 


Lys Val Asp Thr Leu Lys Pro Ile Leu Tyr Lys Ile Asn Ser Asp Ser 
                805                 810                 815     


Asn Asp Phe Tyr Leu Val Ala Asn Tyr Asp Trp Ile Pro Thr Ser Thr 
            820                 825                 830         


Thr Lys Val Tyr Lys Gln Val Pro Gln Pro Phe Asp Phe Arg Ala Ser 
        835                 840                 845             


Met His Met Leu Thr Ser Asn Leu Thr Phe Thr Val Tyr Ser Asp Leu 
    850                 855                 860                 


Leu Ser Phe Val Ser Ala Asp Thr Val Glu Pro Ile Asn Ala Ile Ala 
865                 870                 875                 880 


Phe Asp Asn Met Arg Ile Met Asn Glu Leu 
                885                 890 


<210>  55
<211>  2508
<212>  DNA
<213>  artificial

<220>
<223>  MA104-adapated RV3 VP3

<400>  55
atgaaagtat tagctttaag acacagtgtg gctcaggtgt atgcagatac tcaaacctat       60

ttgcatgatg attcaaaaga tgagtatgaa aatgcatttc tcatttctaa tctaactaca      120

cataatatat tatacctgaa ttacagcctt aaaacattaa aaatattaaa tgaatcaggt      180

atagcagcag ttgaagtaca gtctccagat gaattatttg cgttaataag gtgtaatttt      240

acgtacgatt atgagaataa catagtttat ttacatgatt attcatatta tactaacaat      300

gaaataagaa cagatcaaca ttggataact aaaactgata taattgacta tctattacct      360

ggatggaaat taacatatgt aggctataat ggaaagaaca cacgaggtca ctatgatttt      420

tcatttatat gtcaaaatgc agctacagat gatgatataa taattgaata tatatactcc      480

aatgagttag actttcaaaa ctttctgtta agaaaaatta aagagagaat gaccacatct      540

cttccaattg ctagattatc aaatcgtgtg tttagagata aattatttcc atctattgta      600

aacatacata aaaaagtgat aaacgttggg ccaaggaatg aatctatgtt cacattctta      660

aattttccaa ctattaagca attttcaaac ggtgcgtata ttgtgaagca tactattaaa      720

ttgaagcagg agaaatggtt gggtaaaaga gtatcacaat ttgacatcgg acaatataaa      780

aacatgttaa atgtggttac tactatttac tattactata atttatacta ttcgaaacct      840

ataatataca tgcttggttc agctccatct tattggattt atgatattaa acagtattct      900

gattttacat ttgaaacatg ggatccatta gatactccat attctacaac acatcataaa      960

gaattatttt ttgataagga tgtcaataag cttaaagata attcagtttt atatatagac     1020

ataagaactg atagaggtaa tatggattgg aaagagtgga gaaaaatagt agaacaacaa     1080

actgttagca atctaaatat tgcgtataaa tatctatcaa caggaaaagc aaaggtgtgt     1140

tgtgttaaat taactgctat ggacctagaa ttaccaataa cagcaaaatt acttcatcat     1200

ccaactactg aagttagatc agaattttat gcaatattgg atgtatggga tattattacc     1260

attaaaagat ttataccaaa aggtgtattt tatgctttta taaataatgt aaccacagag     1320

aatgtgttta tacaacctcc tttcaaatta aaaacgtcac ctactgatta catagtggca     1380

ttgtatgctt tatccaatga cttcaactcg aggcaagatg ttattaattt gattaataaa     1440

caaaaacaat cactcattac tgttcgtata aataatactt ttaaagacga accaaaagta     1500

aattttaaaa atatttatga ttggacgttt ctgccaacag attttgaact taaagattcg     1560

ataattacat catatgatgg ttgtttaggc atattcggat tatcgatatc tttatcgtct     1620

aaacccactg gaaataatca tttatttata ataaatggaa ctgacaaata tgataaacta     1680

gaccaatatg caaatcatat gggtatttct agaagatcgc atcaaattag attctcagag     1740

tctgcgacat catattcggg atacattttt agagatcttt caaataataa tttcaatcta     1800

ataggtacta atgtggagaa ttcagtttca ggacatgtct ataatgcatt aatttactat     1860

agatataatt atgcgtttga tcttaaaaga tggatttatc tacattcaat tgggaaagtc     1920

gctgtagagg gtggaagata ttatgaacat gcaccaatcg aactgatata tgcatgccga     1980

tcagctaaag aatttgctat attacaagat gacttaacgg tattgagata cgctaatgaa     2040

attgaagggt atataagcaa agtgtacagt ataacctatg ctgacgatcc caattacttt     2100

ataggaatta aatttaatag tataccttat gaatacgatg ttaaaattcc acatttgacg     2160

ctaggagtat tatttatatc tgataatatg atacatgatg taatcacagt gttgaagaaa     2220

atgaagacag agctatttaa aatggaaatt agtactagtt atacttatat gctatctgat     2280

aatacgtatg tagcaaatgc tagtggtgtg ttatcaactt attttaaatt atataatatg     2340

ttctatagaa attatatcac gtttggacaa tcacgaatgt ttatcccaca cattacgctt     2400

agttttagca acaaacagac ggttagaata gaaagtacaa aactcagaat caattcaatt     2460

tacttaagaa agattaaagg tgaaaccgta tttgatatgt ctgagtga                  2508


<210>  56
<211>  835
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapated RV3 VP3

<400>  56

Met Lys Val Leu Ala Leu Arg His Ser Val Ala Gln Val Tyr Ala Asp 
1               5                   10                  15      


Thr Gln Thr Tyr Leu His Asp Asp Ser Lys Asp Glu Tyr Glu Asn Ala 
            20                  25                  30          


Phe Leu Ile Ser Asn Leu Thr Thr His Asn Ile Leu Tyr Leu Asn Tyr 
        35                  40                  45              


Ser Leu Lys Thr Leu Lys Ile Leu Asn Glu Ser Gly Ile Ala Ala Val 
    50                  55                  60                  


Glu Val Gln Ser Pro Asp Glu Leu Phe Ala Leu Ile Arg Cys Asn Phe 
65                  70                  75                  80  


Thr Tyr Asp Tyr Glu Asn Asn Ile Val Tyr Leu His Asp Tyr Ser Tyr 
                85                  90                  95      


Tyr Thr Asn Asn Glu Ile Arg Thr Asp Gln His Trp Ile Thr Lys Thr 
            100                 105                 110         


Asp Ile Ile Asp Tyr Leu Leu Pro Gly Trp Lys Leu Thr Tyr Val Gly 
        115                 120                 125             


Tyr Asn Gly Lys Asn Thr Arg Gly His Tyr Asp Phe Ser Phe Ile Cys 
    130                 135                 140                 


Gln Asn Ala Ala Thr Asp Asp Asp Ile Ile Ile Glu Tyr Ile Tyr Ser 
145                 150                 155                 160 


Asn Glu Leu Asp Phe Gln Asn Phe Leu Leu Arg Lys Ile Lys Glu Arg 
                165                 170                 175     


Met Thr Thr Ser Leu Pro Ile Ala Arg Leu Ser Asn Arg Val Phe Arg 
            180                 185                 190         


Asp Lys Leu Phe Pro Ser Ile Val Asn Ile His Lys Lys Val Ile Asn 
        195                 200                 205             


Val Gly Pro Arg Asn Glu Ser Met Phe Thr Phe Leu Asn Phe Pro Thr 
    210                 215                 220                 


Ile Lys Gln Phe Ser Asn Gly Ala Tyr Ile Val Lys His Thr Ile Lys 
225                 230                 235                 240 


Leu Lys Gln Glu Lys Trp Leu Gly Lys Arg Val Ser Gln Phe Asp Ile 
                245                 250                 255     


Gly Gln Tyr Lys Asn Met Leu Asn Val Val Thr Thr Ile Tyr Tyr Tyr 
            260                 265                 270         


Tyr Asn Leu Tyr Tyr Ser Lys Pro Ile Ile Tyr Met Leu Gly Ser Ala 
        275                 280                 285             


Pro Ser Tyr Trp Ile Tyr Asp Ile Lys Gln Tyr Ser Asp Phe Thr Phe 
    290                 295                 300                 


Glu Thr Trp Asp Pro Leu Asp Thr Pro Tyr Ser Thr Thr His His Lys 
305                 310                 315                 320 


Glu Leu Phe Phe Asp Lys Asp Val Asn Lys Leu Lys Asp Asn Ser Val 
                325                 330                 335     


Leu Tyr Ile Asp Ile Arg Thr Asp Arg Gly Asn Met Asp Trp Lys Glu 
            340                 345                 350         


Trp Arg Lys Ile Val Glu Gln Gln Thr Val Ser Asn Leu Asn Ile Ala 
        355                 360                 365             


Tyr Lys Tyr Leu Ser Thr Gly Lys Ala Lys Val Cys Cys Val Lys Leu 
    370                 375                 380                 


Thr Ala Met Asp Leu Glu Leu Pro Ile Thr Ala Lys Leu Leu His His 
385                 390                 395                 400 


Pro Thr Thr Glu Val Arg Ser Glu Phe Tyr Ala Ile Leu Asp Val Trp 
                405                 410                 415     


Asp Ile Ile Thr Ile Lys Arg Phe Ile Pro Lys Gly Val Phe Tyr Ala 
            420                 425                 430         


Phe Ile Asn Asn Val Thr Thr Glu Asn Val Phe Ile Gln Pro Pro Phe 
        435                 440                 445             


Lys Leu Lys Thr Ser Pro Thr Asp Tyr Ile Val Ala Leu Tyr Ala Leu 
    450                 455                 460                 


Ser Asn Asp Phe Asn Ser Arg Gln Asp Val Ile Asn Leu Ile Asn Lys 
465                 470                 475                 480 


Gln Lys Gln Ser Leu Ile Thr Val Arg Ile Asn Asn Thr Phe Lys Asp 
                485                 490                 495     


Glu Pro Lys Val Asn Phe Lys Asn Ile Tyr Asp Trp Thr Phe Leu Pro 
            500                 505                 510         


Thr Asp Phe Glu Leu Lys Asp Ser Ile Ile Thr Ser Tyr Asp Gly Cys 
        515                 520                 525             


Leu Gly Ile Phe Gly Leu Ser Ile Ser Leu Ser Ser Lys Pro Thr Gly 
    530                 535                 540                 


Asn Asn His Leu Phe Ile Ile Asn Gly Thr Asp Lys Tyr Asp Lys Leu 
545                 550                 555                 560 


Asp Gln Tyr Ala Asn His Met Gly Ile Ser Arg Arg Ser His Gln Ile 
                565                 570                 575     


Arg Phe Ser Glu Ser Ala Thr Ser Tyr Ser Gly Tyr Ile Phe Arg Asp 
            580                 585                 590         


Leu Ser Asn Asn Asn Phe Asn Leu Ile Gly Thr Asn Val Glu Asn Ser 
        595                 600                 605             


Val Ser Gly His Val Tyr Asn Ala Leu Ile Tyr Tyr Arg Tyr Asn Tyr 
    610                 615                 620                 


Ala Phe Asp Leu Lys Arg Trp Ile Tyr Leu His Ser Ile Gly Lys Val 
625                 630                 635                 640 


Ala Val Glu Gly Gly Arg Tyr Tyr Glu His Ala Pro Ile Glu Leu Ile 
                645                 650                 655     


Tyr Ala Cys Arg Ser Ala Lys Glu Phe Ala Ile Leu Gln Asp Asp Leu 
            660                 665                 670         


Thr Val Leu Arg Tyr Ala Asn Glu Ile Glu Gly Tyr Ile Ser Lys Val 
        675                 680                 685             


Tyr Ser Ile Thr Tyr Ala Asp Asp Pro Asn Tyr Phe Ile Gly Ile Lys 
    690                 695                 700                 


Phe Asn Ser Ile Pro Tyr Glu Tyr Asp Val Lys Ile Pro His Leu Thr 
705                 710                 715                 720 


Leu Gly Val Leu Phe Ile Ser Asp Asn Met Ile His Asp Val Ile Thr 
                725                 730                 735     


Val Leu Lys Lys Met Lys Thr Glu Leu Phe Lys Met Glu Ile Ser Thr 
            740                 745                 750         


Ser Tyr Thr Tyr Met Leu Ser Asp Asn Thr Tyr Val Ala Asn Ala Ser 
        755                 760                 765             


Gly Val Leu Ser Thr Tyr Phe Lys Leu Tyr Asn Met Phe Tyr Arg Asn 
    770                 775                 780                 


Tyr Ile Thr Phe Gly Gln Ser Arg Met Phe Ile Pro His Ile Thr Leu 
785                 790                 795                 800 


Ser Phe Ser Asn Lys Gln Thr Val Arg Ile Glu Ser Thr Lys Leu Arg 
                805                 810                 815     


Ile Asn Ser Ile Tyr Leu Arg Lys Ile Lys Gly Glu Thr Val Phe Asp 
            820                 825                 830         


Met Ser Glu 
        835 


<210>  57
<211>  2591
<212>  DNA
<213>  artificial

<220>
<223>  Vero-adapated RV3 VP3

<400>  57
ggctattaaa gcagtaccag tagtgtgttt tacctctgat ggtgtaagca tgaaagtatt       60

agctttaaga cacagtgtgg ctcaggtgta tgcagatact caaacctatt tgcatgatga      120

ttcaaaagat gagtatgaaa atgcatttct catttctaat ctaactacac ataatatatt      180

atacctgaat tacagcctta aaacattaaa aatattaaat gaatcaggta tagcagcagt      240

tgaagtacag tctccagatg aattatttgc gttaataagg tgtaatttta cgtacgatta      300

tgagaataac atagtttatt tacatgatta ttcatattat accaacaatg aaataagaac      360

agatcaacat tggataacta aaactgatat aattgactat ctattacctg gatggaaatt      420

aacatatgta ggctataatg gaaagaacac acgaggtcac tatgattttt catttatatg      480

tcaaaatgca gctacagatg atgatataat aattgaatat atatactcca atgagttaga      540

ctttcaaaac tttctgttaa gaaaaattaa agagagaatg accacatctc ttccaattgc      600

tagattatca aatcgtgtgt ttagagataa attatttcca tctattgtaa acatacataa      660

aaaagtgata aacgttgggc caaggaatga atctatgttc acattcttaa attttccaac      720

tattaagcaa ttttcaaacg gtgcgtatat tgtgaagcat actattaaat tgaagcagga      780

gaaatggttg ggtaaaagag tatcacaatt tgacatcgga caatataaaa acatgttaaa      840

tgtggttact actatttact attactataa tttatactat tcgaaaccta taatatacat      900

gcttggttca gctccatctt attggattta tgatattaaa cagtattctg attttacatt      960

tgaaacatgg gatccattag atactccata ttctacaaca catcataaag aattattttt     1020

tgataaggat gtcaataagc ttaaagataa ttcagtttta tatatagaca taagaactga     1080

tagaggtaat atggattgga aagagtggag aaaaatagta gaacaacaaa ctgttagcaa     1140

tctaaatatt gcgtataaat atctatcaac aggaaaagca aaggtgtgtt gtgttaaatt     1200

aactgctatg gacctagaat taccaataac agcaaaatta cttcatcatc caactactga     1260

agttagatca gaattttatg caatattgga tgtatgggat attattacca ttaaaagatt     1320

tataccaaaa ggtgtatttt atgcttttat aaataatgta accacggaga atgtgtttat     1380

acaacctcct ttcaaattaa aaacgtcacc tactgattac atagtggcat tgtatgcttt     1440

atccaatgac ttcaactcga ggcaagatgt tattaatttg attaataaac aaaaacaatc     1500

actcattact gttcgtataa ataatacttt taaagacgaa ccaaaagtaa attttaaaaa     1560

tatttatgat tggacgtttc tgccaacaga ttttgaactt aaagattcga taattacatc     1620

atatgatggt tgtttaggca tattcggatt atcgatatct ttatcgtcta aacccactgg     1680

aaataatcat ttatttataa taaatggaac tgacaaatat gataaactag accaatatgc     1740

aaaccatatg ggtatttcta gaagatcgca tcaaattaga ttctcagagt ctgcgacatc     1800

atattcggga tacattttta gagatctttc aaataataat ttcaatctaa taggtactaa     1860

tgtggagaat tcagtttcag gacatgtcta taatgcatta atttactata gatataatta     1920

tgcgtttgat cttaaaagat ggatttatct acattcaatt gggaaagtcg ctgtaaaggg     1980

tggaagatat tatgaacatg caccaatcga actgatatat gcatgccgat cagctaaaga     2040

atttgctata ttacaagatg acttaacggt attgagatac gctaatgaaa ttgaagggta     2100

tataagcaaa gtgtacagta taacctatgc tgacgatccc aattacttta taggaattaa     2160

atttaatagt ataccttatg aatacgatgt taaaattcca catttgacgc taggagtatt     2220

atttatatct gataatatga tacatgatgt aatcacagtg ttgaagaaaa tgaagacaga     2280

gctatttaaa atggaaatta gtactagtta tacttatatg ctatctgata atacgtatgt     2340

agcaaatgct agtggtgtgt tatcaactta ttttaaatta tataatatgt tctatagaaa     2400

tcatatcacg tttggacaat cacgaatgtt tatcccacac attacgctta gttttagcaa     2460

caaacagacg gttagaatag aaagtacaaa actcagaatc aattcaattt acttaagaaa     2520

gattaaaggt gaaaccgtat ttgatatgtc tgagtgagct agaaacttaa cacactagtc     2580

atgatgtgac c                                                          2591


<210>  58
<211>  835
<212>  PRT
<213>  artificial

<220>
<223>  Vero-adapated RV3 VP3

<400>  58

Met Lys Val Leu Ala Leu Arg His Ser Val Ala Gln Val Tyr Ala Asp 
1               5                   10                  15      


Thr Gln Thr Tyr Leu His Asp Asp Ser Lys Asp Glu Tyr Glu Asn Ala 
            20                  25                  30          


Phe Leu Ile Ser Asn Leu Thr Thr His Asn Ile Leu Tyr Leu Asn Tyr 
        35                  40                  45              


Ser Leu Lys Thr Leu Lys Ile Leu Asn Glu Ser Gly Ile Ala Ala Val 
    50                  55                  60                  


Glu Val Gln Ser Pro Asp Glu Leu Phe Ala Leu Ile Arg Cys Asn Phe 
65                  70                  75                  80  


Thr Tyr Asp Tyr Glu Asn Asn Ile Val Tyr Leu His Asp Tyr Ser Tyr 
                85                  90                  95      


Tyr Thr Asn Asn Glu Ile Arg Thr Asp Gln His Trp Ile Thr Lys Thr 
            100                 105                 110         


Asp Ile Ile Asp Tyr Leu Leu Pro Gly Trp Lys Leu Thr Tyr Val Gly 
        115                 120                 125             


Tyr Asn Gly Lys Asn Thr Arg Gly His Tyr Asp Phe Ser Phe Ile Cys 
    130                 135                 140                 


Gln Asn Ala Ala Thr Asp Asp Asp Ile Ile Ile Glu Tyr Ile Tyr Ser 
145                 150                 155                 160 


Asn Glu Leu Asp Phe Gln Asn Phe Leu Leu Arg Lys Ile Lys Glu Arg 
                165                 170                 175     


Met Thr Thr Ser Leu Pro Ile Ala Arg Leu Ser Asn Arg Val Phe Arg 
            180                 185                 190         


Asp Lys Leu Phe Pro Ser Ile Val Asn Ile His Lys Lys Val Ile Asn 
        195                 200                 205             


Val Gly Pro Arg Asn Glu Ser Met Phe Thr Phe Leu Asn Phe Pro Thr 
    210                 215                 220                 


Ile Lys Gln Phe Ser Asn Gly Ala Tyr Ile Val Lys His Thr Ile Lys 
225                 230                 235                 240 


Leu Lys Gln Glu Lys Trp Leu Gly Lys Arg Val Ser Gln Phe Asp Ile 
                245                 250                 255     


Gly Gln Tyr Lys Asn Met Leu Asn Val Val Thr Thr Ile Tyr Tyr Tyr 
            260                 265                 270         


Tyr Asn Leu Tyr Tyr Ser Lys Pro Ile Ile Tyr Met Leu Gly Ser Ala 
        275                 280                 285             


Pro Ser Tyr Trp Ile Tyr Asp Ile Lys Gln Tyr Ser Asp Phe Thr Phe 
    290                 295                 300                 


Glu Thr Trp Asp Pro Leu Asp Thr Pro Tyr Ser Thr Thr His His Lys 
305                 310                 315                 320 


Glu Leu Phe Phe Asp Lys Asp Val Asn Lys Leu Lys Asp Asn Ser Val 
                325                 330                 335     


Leu Tyr Ile Asp Ile Arg Thr Asp Arg Gly Asn Met Asp Trp Lys Glu 
            340                 345                 350         


Trp Arg Lys Ile Val Glu Gln Gln Thr Val Ser Asn Leu Asn Ile Ala 
        355                 360                 365             


Tyr Lys Tyr Leu Ser Thr Gly Lys Ala Lys Val Cys Cys Val Lys Leu 
    370                 375                 380                 


Thr Ala Met Asp Leu Glu Leu Pro Ile Thr Ala Lys Leu Leu His His 
385                 390                 395                 400 


Pro Thr Thr Glu Val Arg Ser Glu Phe Tyr Ala Ile Leu Asp Val Trp 
                405                 410                 415     


Asp Ile Ile Thr Ile Lys Arg Phe Ile Pro Lys Gly Val Phe Tyr Ala 
            420                 425                 430         


Phe Ile Asn Asn Val Thr Thr Glu Asn Val Phe Ile Gln Pro Pro Phe 
        435                 440                 445             


Lys Leu Lys Thr Ser Pro Thr Asp Tyr Ile Val Ala Leu Tyr Ala Leu 
    450                 455                 460                 


Ser Asn Asp Phe Asn Ser Arg Gln Asp Val Ile Asn Leu Ile Asn Lys 
465                 470                 475                 480 


Gln Lys Gln Ser Leu Ile Thr Val Arg Ile Asn Asn Thr Phe Lys Asp 
                485                 490                 495     


Glu Pro Lys Val Asn Phe Lys Asn Ile Tyr Asp Trp Thr Phe Leu Pro 
            500                 505                 510         


Thr Asp Phe Glu Leu Lys Asp Ser Ile Ile Thr Ser Tyr Asp Gly Cys 
        515                 520                 525             


Leu Gly Ile Phe Gly Leu Ser Ile Ser Leu Ser Ser Lys Pro Thr Gly 
    530                 535                 540                 


Asn Asn His Leu Phe Ile Ile Asn Gly Thr Asp Lys Tyr Asp Lys Leu 
545                 550                 555                 560 


Asp Gln Tyr Ala Asn His Met Gly Ile Ser Arg Arg Ser His Gln Ile 
                565                 570                 575     


Arg Phe Ser Glu Ser Ala Thr Ser Tyr Ser Gly Tyr Ile Phe Arg Asp 
            580                 585                 590         


Leu Ser Asn Asn Asn Phe Asn Leu Ile Gly Thr Asn Val Glu Asn Ser 
        595                 600                 605             


Val Ser Gly His Val Tyr Asn Ala Leu Ile Tyr Tyr Arg Tyr Asn Tyr 
    610                 615                 620                 


Ala Phe Asp Leu Lys Arg Trp Ile Tyr Leu His Ser Ile Gly Lys Val 
625                 630                 635                 640 


Ala Val Lys Gly Gly Arg Tyr Tyr Glu His Ala Pro Ile Glu Leu Ile 
                645                 650                 655     


Tyr Ala Cys Arg Ser Ala Lys Glu Phe Ala Ile Leu Gln Asp Asp Leu 
            660                 665                 670         


Thr Val Leu Arg Tyr Ala Asn Glu Ile Glu Gly Tyr Ile Ser Lys Val 
        675                 680                 685             


Tyr Ser Ile Thr Tyr Ala Asp Asp Pro Asn Tyr Phe Ile Gly Ile Lys 
    690                 695                 700                 


Phe Asn Ser Ile Pro Tyr Glu Tyr Asp Val Lys Ile Pro His Leu Thr 
705                 710                 715                 720 


Leu Gly Val Leu Phe Ile Ser Asp Asn Met Ile His Asp Val Ile Thr 
                725                 730                 735     


Val Leu Lys Lys Met Lys Thr Glu Leu Phe Lys Met Glu Ile Ser Thr 
            740                 745                 750         


Ser Tyr Thr Tyr Met Leu Ser Asp Asn Thr Tyr Val Ala Asn Ala Ser 
        755                 760                 765             


Gly Val Leu Ser Thr Tyr Phe Lys Leu Tyr Asn Met Phe Tyr Arg Asn 
    770                 775                 780                 


His Ile Thr Phe Gly Gln Ser Arg Met Phe Ile Pro His Ile Thr Leu 
785                 790                 795                 800 


Ser Phe Ser Asn Lys Gln Thr Val Arg Ile Glu Ser Thr Lys Leu Arg 
                805                 810                 815     


Ile Asn Ser Ile Tyr Leu Arg Lys Ile Lys Gly Glu Thr Val Phe Asp 
            820                 825                 830         


Met Ser Glu 
        835 


<210>  59
<211>  2328
<212>  DNA
<213>  artificial

<220>
<223>  MA104-adapted RV3 VP4

<400>  59
atggcttcac tcatttatag acagctactc actaattcat acacagttga attatcagat       60

gagattaata cgattggatc agaaaaaagt caaaatgtaa cgattaatcc cggaccgttt      120

gctcaaccaa attatgcacg agtaacttgg agtcatgggg aagtgaatga ttcgacaaca      180

atagagccag tacttgatgg cccttatcaa tcaacaagtt ttaagccacc aagcgattac      240

tggatattat tgaatccaac taatcaacaa gttgtattag agggtaccaa taaaactgat      300

atttgggttg ccttattact tgttgaacca aacgtaacca atcaaagtag acaatacaca      360

ttatttggag aaacgaaaca aattactgta gaaaataaca caaacaaatg gaaattcttc      420

gaaatgttca gaagcagtgt tagtgccgaa tttcaacata agcgcacttt aacatcagac      480

actaaattag ctgggttttt aaaacattat aacagtgttt ggactttcca cggtgaaacg      540

ccacatgcta caactgatta ctcatcaact tcaaatttat ctgaagtaga aactacaata      600

catgttgagt tttatataat accaagatcg caggaatcta agtgtgttga atatataaat      660

actggattgc caccaatgca gaatacaagg aatatagttc cagttgcact atcatctaga      720

gcagtgactt atcaacgtgc tcaggttaat gaagatatca tcatatcaaa gacatcgttg      780

tggaaggaaa tgcaatataa cagagacatc gtaataaggt ttaaatttaa taatagtata      840

gtaaaacttg gtgggctagg ttataaatgg tcagaaattt cgtttaaagc tgctaattat      900

cagtacaatt acttgcgaga tggagaacaa gttacggcac atactacttg ttcagtcaat      960

ggtgtgaata acttcagtta taatggagga tcactgccaa ctgattttag tgtatcaaga     1020

tatgaagtga ttaaggagaa ttcttatgtc tatgttgatt attgggatga ttcacaagca     1080

tttaggaaca tggtatacgt caggtcattg gcagcaaatt taaattcagt aaagtgtagt     1140

ggaggaaatt atgattttca aataccagtt ggtgcatggc cagtgatgag tggaggtgcg     1200

gtatctttgc attttgcggg agtcacctta tccactcaat ttactgactt tgtatcactt     1260

aattcgttaa gatttagatt cagtttgacc gttgaagatc cacctttttc aatttcacgc     1320

acacgtgtgt caggattata cgggctacca gcatttaatc cgaatagcgg acatgaatat     1380

tatgaaatag ctgggggatt ttctcttatt tcattagtac cgtctaatga cgattatcaa     1440

actccaatca tgaattcagt tacagtgcga caagatcttg aacgtcaact aggtgattta     1500

agggaggaat tcaattctct atcacaagaa atagcgatga cgcaattgat agatttagca     1560

ttattaccgt tagatatgtt ttctatgttc tcaggtatta aaagcacaat tgacgcagct     1620

aaatcaatgg ccacaaaggt gatgaaaaag tttaagagat cgggattagc tacatcaatc     1680

tctgaattaa ctggatcatt atcaaacgct gcttcatcag tttccagaag ttcatctatt     1740

agatctaaca tatcatccat ttcagtgtgg acggatgttt ccgaacagat agcgggttcg     1800

tcagactctg tcaggaatat ttccacgcaa acgtcagcta ttagtagaag attgcgacta     1860

cgcgaaatta ctacacaaac tgaaggtatg aattttgatg atatttcagc ggcagttctt     1920

aaaactaaga tagataaatc aactcatata agcccagata cattaccaga cataataact     1980

gagtcatctg aaaaattcat accaaaacga gcttatagag ttctaaaaga tgatgaagtg     2040

atggaagctg acgtggatgg gaagttcttt gcatataagg ttgacacttt tgaagaagtg     2100

ccatttgacg tagataaatt tgtcgatttg gtaactgatt ctcctgtaat ttcagctata     2160

atcgatttta agacgttgaa gaatttaaac gacaattatg gtataacgcg atctcaagcg     2220

ttagacttaa tcagatctga tcccagagtt ttacgcgatt ttatcaatca gaataatcca     2280

attattaaaa atagaattga acagctaata ctgcaatgta gactgtga                  2328


<210>  60
<211>  775
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapated RV3 VP4

<400>  60

Met Ala Ser Leu Ile Tyr Arg Gln Leu Leu Thr Asn Ser Tyr Thr Val 
1               5                   10                  15      


Glu Leu Ser Asp Glu Ile Asn Thr Ile Gly Ser Glu Lys Ser Gln Asn 
            20                  25                  30          


Val Thr Ile Asn Pro Gly Pro Phe Ala Gln Pro Asn Tyr Ala Arg Val 
        35                  40                  45              


Thr Trp Ser His Gly Glu Val Asn Asp Ser Thr Thr Ile Glu Pro Val 
    50                  55                  60                  


Leu Asp Gly Pro Tyr Gln Ser Thr Ser Phe Lys Pro Pro Ser Asp Tyr 
65                  70                  75                  80  


Trp Ile Leu Leu Asn Pro Thr Asn Gln Gln Val Val Leu Glu Gly Thr 
                85                  90                  95      


Asn Lys Thr Asp Ile Trp Val Ala Leu Leu Leu Val Glu Pro Asn Val 
            100                 105                 110         


Thr Asn Gln Ser Arg Gln Tyr Thr Leu Phe Gly Glu Thr Lys Gln Ile 
        115                 120                 125             


Thr Val Glu Asn Asn Thr Asn Lys Trp Lys Phe Phe Glu Met Phe Arg 
    130                 135                 140                 


Ser Ser Val Ser Ala Glu Phe Gln His Lys Arg Thr Leu Thr Ser Asp 
145                 150                 155                 160 


Thr Lys Leu Ala Gly Phe Leu Lys His Tyr Asn Ser Val Trp Thr Phe 
                165                 170                 175     


His Gly Glu Thr Pro His Ala Thr Thr Asp Tyr Ser Ser Thr Ser Asn 
            180                 185                 190         


Leu Ser Glu Val Glu Thr Thr Ile His Val Glu Phe Tyr Ile Ile Pro 
        195                 200                 205             


Arg Ser Gln Glu Ser Lys Cys Val Glu Tyr Ile Asn Thr Gly Leu Pro 
    210                 215                 220                 


Pro Met Gln Asn Thr Arg Asn Ile Val Pro Val Ala Leu Ser Ser Arg 
225                 230                 235                 240 


Ala Val Thr Tyr Gln Arg Ala Gln Val Asn Glu Asp Ile Ile Ile Ser 
                245                 250                 255     


Lys Thr Ser Leu Trp Lys Glu Met Gln Tyr Asn Arg Asp Ile Val Ile 
            260                 265                 270         


Arg Phe Lys Phe Asn Asn Ser Ile Val Lys Leu Gly Gly Leu Gly Tyr 
        275                 280                 285             


Lys Trp Ser Glu Ile Ser Phe Lys Ala Ala Asn Tyr Gln Tyr Asn Tyr 
    290                 295                 300                 


Leu Arg Asp Gly Glu Gln Val Thr Ala His Thr Thr Cys Ser Val Asn 
305                 310                 315                 320 


Gly Val Asn Asn Phe Ser Tyr Asn Gly Gly Ser Leu Pro Thr Asp Phe 
                325                 330                 335     


Ser Val Ser Arg Tyr Glu Val Ile Lys Glu Asn Ser Tyr Val Tyr Val 
            340                 345                 350         


Asp Tyr Trp Asp Asp Ser Gln Ala Phe Arg Asn Met Val Tyr Val Arg 
        355                 360                 365             


Ser Leu Ala Ala Asn Leu Asn Ser Val Lys Cys Ser Gly Gly Asn Tyr 
    370                 375                 380                 


Asp Phe Gln Ile Pro Val Gly Ala Trp Pro Val Met Ser Gly Gly Ala 
385                 390                 395                 400 


Val Ser Leu His Phe Ala Gly Val Thr Leu Ser Thr Gln Phe Thr Asp 
                405                 410                 415     


Phe Val Ser Leu Asn Ser Leu Arg Phe Arg Phe Ser Leu Thr Val Glu 
            420                 425                 430         


Asp Pro Pro Phe Ser Ile Ser Arg Thr Arg Val Ser Gly Leu Tyr Gly 
        435                 440                 445             


Leu Pro Ala Phe Asn Pro Asn Ser Gly His Glu Tyr Tyr Glu Ile Ala 
    450                 455                 460                 


Gly Gly Phe Ser Leu Ile Ser Leu Val Pro Ser Asn Asp Asp Tyr Gln 
465                 470                 475                 480 


Thr Pro Ile Met Asn Ser Val Thr Val Arg Gln Asp Leu Glu Arg Gln 
                485                 490                 495     


Leu Gly Asp Leu Arg Glu Glu Phe Asn Ser Leu Ser Gln Glu Ile Ala 
            500                 505                 510         


Met Thr Gln Leu Ile Asp Leu Ala Leu Leu Pro Leu Asp Met Phe Ser 
        515                 520                 525             


Met Phe Ser Gly Ile Lys Ser Thr Ile Asp Ala Ala Lys Ser Met Ala 
    530                 535                 540                 


Thr Lys Val Met Lys Lys Phe Lys Arg Ser Gly Leu Ala Thr Ser Ile 
545                 550                 555                 560 


Ser Glu Leu Thr Gly Ser Leu Ser Asn Ala Ala Ser Ser Val Ser Arg 
                565                 570                 575     


Ser Ser Ser Ile Arg Ser Asn Ile Ser Ser Ile Ser Val Trp Thr Asp 
            580                 585                 590         


Val Ser Glu Gln Ile Ala Gly Ser Ser Asp Ser Val Arg Asn Ile Ser 
        595                 600                 605             


Thr Gln Thr Ser Ala Ile Ser Arg Arg Leu Arg Leu Arg Glu Ile Thr 
    610                 615                 620                 


Thr Gln Thr Glu Gly Met Asn Phe Asp Asp Ile Ser Ala Ala Val Leu 
625                 630                 635                 640 


Lys Thr Lys Ile Asp Lys Ser Thr His Ile Ser Pro Asp Thr Leu Pro 
                645                 650                 655     


Asp Ile Ile Thr Glu Ser Ser Glu Lys Phe Ile Pro Lys Arg Ala Tyr 
            660                 665                 670         


Arg Val Leu Lys Asp Asp Glu Val Met Glu Ala Asp Val Asp Gly Lys 
        675                 680                 685             


Phe Phe Ala Tyr Lys Val Asp Thr Phe Glu Glu Val Pro Phe Asp Val 
    690                 695                 700                 


Asp Lys Phe Val Asp Leu Val Thr Asp Ser Pro Val Ile Ser Ala Ile 
705                 710                 715                 720 


Ile Asp Phe Lys Thr Leu Lys Asn Leu Asn Asp Asn Tyr Gly Ile Thr 
                725                 730                 735     


Arg Ser Gln Ala Leu Asp Leu Ile Arg Ser Asp Pro Arg Val Leu Arg 
            740                 745                 750         


Asp Phe Ile Asn Gln Asn Asn Pro Ile Ile Lys Asn Arg Ile Glu Gln 
        755                 760                 765             


Leu Ile Leu Gln Cys Arg Leu 
    770                 775 


<210>  61
<211>  2378
<212>  DNA
<213>  artificial

<220>
<223>  Vero-adapated RV3 VP4

<400>  61
ggctataaaa tggcttcact catttataga cagctactca ctaattcata cacagttgaa       60

ttatcagatg agattaatac gattggatca gaaaaaagtc aaaatgtaac gattaatccc      120

ggaccgtttg ctcaaacaaa ttatgcacga gtaacttgga gtcatgggga agtgaatgat      180

tcgacaacaa tagagccagt acttgatggc ccttatcaat caacaagttt taagccacca      240

agcgattact ggatattatt gaatccaact aatcaacaag ttgtattaga gggtaccaat      300

aaaactgata tttgggttgc cttattactt gttgaaccaa acgtaaccaa tcaaagtaga      360

caatacacgt tatttggaga aacgaaacaa attactgtag aaaataacac aaacaaatgg      420

aaattcttcg aaatgttcag aagcagtgtt agtgccgaat ttcaacataa gcgcacttta      480

acatcagaca ctaaattagc tgggttttta aaacattata acagtgtttg gactttccac      540

ggtgaaacgc cacatgctac aactgattac tcatcaactt caaatttatc tgaagtagaa      600

actacaatac atgttgagtt ttatataata ccaagatcgc aggaatctaa gtgtgttgaa      660

tatataaata ctggattgcc accaatgcag aatacaagga atatagttcc agttgcacta      720

tcatctagag cagtgactta tcaacgtgct caggttaatg aagatatcat catatcaaag      780

acatcgttgt ggaaggaaat gcaatataac agagacatcg taataaggtt taaatttaat      840

aatagtatag taaaacttgg tgggctaggt tataaatggt cagaaatttc gtttaaagct      900

gctaattatc agtacaatta cttgcgagat ggagaacaag ttacggcaca tactacttgt      960

tcagtcaatg gtgtgaataa cttcagttat aatggaggat cactgccaac tgattttagt     1020

gtatcaagat atgaagtgat taaggagaat tcttatgtct atgttgatta ttgggatgat     1080

tcacaagcat ttaggaacat ggtatacgtc aggtcattgg cagcaaattc aaattcagta     1140

aagtgtagtg gaggaaatta taattttcaa ctaccagttg gtgcatggcc agtgatgagt     1200

ggaggtgcgg tatctttgca ttttgcggga gtcaccttat ccactcaatt tactgacttt     1260

gtatcactta attcgttaag atttagattc agtttgaccg ttgaagatcc acctttttca     1320

atttcacgca cacatgtgtc aggattatac gggctaccag catttaatcc gaatagcgga     1380

catgaatatt atgaaatagc tgggggattt tctcttattt cattagtacc gtctaatgac     1440

gattatcaaa ctccaatcat gaattcagtt acagtgcgac aagatcttga acgtcaacta     1500

ggtgatttaa gggaggaatt caattctcta tcacaagaaa tagcgatgac gcaattgata     1560

gatttagcat tattaccgtt agatatgttt tctatgttct caggtattaa aagcacaatt     1620

gacgcagcta aatcaatggc cacaaaggtg atgaaaaagt ttaagagatc gggattagct     1680

acatcaatct ctgaattaac tggatcatta tcaaacgctg cttcatcagt ttccagaagt     1740

tcatctatta gatctaacat atcatccatt tcagtgtgga cggatgtttc cgaacagata     1800

gcgggttcgt cagactctgt caggaatatt tccacgcaaa cgtcagctat tagtagaaga     1860

ttgcgactac gcgaaattac tacacaaact gaaggtatga attttgatga tatttcagcg     1920

gcagttctta aaactaagat agataaatca actcatataa gcccagatac attaccagac     1980

ataataactg agtcatctga aaaattcata ccaaaacgag cttatagagt tctaaaagat     2040

gatgaagtga tggaagctga cgtggatggg aagttctttg catataaggt tgacactttt     2100

gaagaagtgc catttgacgt agataaattt gtcgatttgg taactgattc tcctgtaatt     2160

tcagctataa tcgattttaa gacgttgaag aatttaaacg acaattatgg tataacgcga     2220

tctcaagcgt tagacttaat cagatctgat cccagagttt tacgcgattt tatcattcag     2280

aataatccaa ttattaaaaa tagaattgaa cagctaatac tgcaatgtag actgtgagag     2340

ctccatcgag gaatgtgacc ggtcatagct gtttcctg                             2378


<210>  62
<211>  775
<212>  PRT
<213>  artificial

<220>
<223>  Vero-adapted RV3 VP4

<400>  62

Met Ala Ser Leu Ile Tyr Arg Gln Leu Leu Thr Asn Ser Tyr Thr Val 
1               5                   10                  15      


Glu Leu Ser Asp Glu Ile Asn Thr Ile Gly Ser Glu Lys Ser Gln Asn 
            20                  25                  30          


Val Thr Ile Asn Pro Gly Pro Phe Ala Gln Thr Asn Tyr Ala Arg Val 
        35                  40                  45              


Thr Trp Ser His Gly Glu Val Asn Asp Ser Thr Thr Ile Glu Pro Val 
    50                  55                  60                  


Leu Asp Gly Pro Tyr Gln Ser Thr Ser Phe Lys Pro Pro Ser Asp Tyr 
65                  70                  75                  80  


Trp Ile Leu Leu Asn Pro Thr Asn Gln Gln Val Val Leu Glu Gly Thr 
                85                  90                  95      


Asn Lys Thr Asp Ile Trp Val Ala Leu Leu Leu Val Glu Pro Asn Val 
            100                 105                 110         


Thr Asn Gln Ser Arg Gln Tyr Thr Leu Phe Gly Glu Thr Lys Gln Ile 
        115                 120                 125             


Thr Val Glu Asn Asn Thr Asn Lys Trp Lys Phe Phe Glu Met Phe Arg 
    130                 135                 140                 


Ser Ser Val Ser Ala Glu Phe Gln His Lys Arg Thr Leu Thr Ser Asp 
145                 150                 155                 160 


Thr Lys Leu Ala Gly Phe Leu Lys His Tyr Asn Ser Val Trp Thr Phe 
                165                 170                 175     


His Gly Glu Thr Pro His Ala Thr Thr Asp Tyr Ser Ser Thr Ser Asn 
            180                 185                 190         


Leu Ser Glu Val Glu Thr Thr Ile His Val Glu Phe Tyr Ile Ile Pro 
        195                 200                 205             


Arg Ser Gln Glu Ser Lys Cys Val Glu Tyr Ile Asn Thr Gly Leu Pro 
    210                 215                 220                 


Pro Met Gln Asn Thr Arg Asn Ile Val Pro Val Ala Leu Ser Ser Arg 
225                 230                 235                 240 


Ala Val Thr Tyr Gln Arg Ala Gln Val Asn Glu Asp Ile Ile Ile Ser 
                245                 250                 255     


Lys Thr Ser Leu Trp Lys Glu Met Gln Tyr Asn Arg Asp Ile Val Ile 
            260                 265                 270         


Arg Phe Lys Phe Asn Asn Ser Ile Val Lys Leu Gly Gly Leu Gly Tyr 
        275                 280                 285             


Lys Trp Ser Glu Ile Ser Phe Lys Ala Ala Asn Tyr Gln Tyr Asn Tyr 
    290                 295                 300                 


Leu Arg Asp Gly Glu Gln Val Thr Ala His Thr Thr Cys Ser Val Asn 
305                 310                 315                 320 


Gly Val Asn Asn Phe Ser Tyr Asn Gly Gly Ser Leu Pro Thr Asp Phe 
                325                 330                 335     


Ser Val Ser Arg Tyr Glu Val Ile Lys Glu Asn Ser Tyr Val Tyr Val 
            340                 345                 350         


Asp Tyr Trp Asp Asp Ser Gln Ala Phe Arg Asn Met Val Tyr Val Arg 
        355                 360                 365             


Ser Leu Ala Ala Asn Ser Asn Ser Val Lys Cys Ser Gly Gly Asn Tyr 
    370                 375                 380                 


Asn Phe Gln Leu Pro Val Gly Ala Trp Pro Val Met Ser Gly Gly Ala 
385                 390                 395                 400 


Val Ser Leu His Phe Ala Gly Val Thr Leu Ser Thr Gln Phe Thr Asp 
                405                 410                 415     


Phe Val Ser Leu Asn Ser Leu Arg Phe Arg Phe Ser Leu Thr Val Glu 
            420                 425                 430         


Asp Pro Pro Phe Ser Ile Ser Arg Thr His Val Ser Gly Leu Tyr Gly 
        435                 440                 445             


Leu Pro Ala Phe Asn Pro Asn Ser Gly His Glu Tyr Tyr Glu Ile Ala 
    450                 455                 460                 


Gly Gly Phe Ser Leu Ile Ser Leu Val Pro Ser Asn Asp Asp Tyr Gln 
465                 470                 475                 480 


Thr Pro Ile Met Asn Ser Val Thr Val Arg Gln Asp Leu Glu Arg Gln 
                485                 490                 495     


Leu Gly Asp Leu Arg Glu Glu Phe Asn Ser Leu Ser Gln Glu Ile Ala 
            500                 505                 510         


Met Thr Gln Leu Ile Asp Leu Ala Leu Leu Pro Leu Asp Met Phe Ser 
        515                 520                 525             


Met Phe Ser Gly Ile Lys Ser Thr Ile Asp Ala Ala Lys Ser Met Ala 
    530                 535                 540                 


Thr Lys Val Met Lys Lys Phe Lys Arg Ser Gly Leu Ala Thr Ser Ile 
545                 550                 555                 560 


Ser Glu Leu Thr Gly Ser Leu Ser Asn Ala Ala Ser Ser Val Ser Arg 
                565                 570                 575     


Ser Ser Ser Ile Arg Ser Asn Ile Ser Ser Ile Ser Val Trp Thr Asp 
            580                 585                 590         


Val Ser Glu Gln Ile Ala Gly Ser Ser Asp Ser Val Arg Asn Ile Ser 
        595                 600                 605             


Thr Gln Thr Ser Ala Ile Ser Arg Arg Leu Arg Leu Arg Glu Ile Thr 
    610                 615                 620                 


Thr Gln Thr Glu Gly Met Asn Phe Asp Asp Ile Ser Ala Ala Val Leu 
625                 630                 635                 640 


Lys Thr Lys Ile Asp Lys Ser Thr His Ile Ser Pro Asp Thr Leu Pro 
                645                 650                 655     


Asp Ile Ile Thr Glu Ser Ser Glu Lys Phe Ile Pro Lys Arg Ala Tyr 
            660                 665                 670         


Arg Val Leu Lys Asp Asp Glu Val Met Glu Ala Asp Val Asp Gly Lys 
        675                 680                 685             


Phe Phe Ala Tyr Lys Val Asp Thr Phe Glu Glu Val Pro Phe Asp Val 
    690                 695                 700                 


Asp Lys Phe Val Asp Leu Val Thr Asp Ser Pro Val Ile Ser Ala Ile 
705                 710                 715                 720 


Ile Asp Phe Lys Thr Leu Lys Asn Leu Asn Asp Asn Tyr Gly Ile Thr 
                725                 730                 735     


Arg Ser Gln Ala Leu Asp Leu Ile Arg Ser Asp Pro Arg Val Leu Arg 
            740                 745                 750         


Asp Phe Ile Ile Gln Asn Asn Pro Ile Ile Lys Asn Arg Ile Glu Gln 
        755                 760                 765             


Leu Ile Leu Gln Cys Arg Leu 
    770                 775 


<210>  63
<211>  981
<212>  DNA
<213>  artificial

<220>
<223>  MA104-adapated RV3 VP7

<400>  63
atgtatggta ttgaatatac cacagttttg acctttttga tatcaattat attgttgaat       60

tacgtactca aatcattaac tagaataatg gactttatta tctacagatt tcttttgatt      120

atagttatac tgtcaccact ccttaatgca caaaattatg gaataaatct tccgattact      180

ggatcaatgg acacaccata tacgaactca acgcgagagg aagtattcct aacttcgact      240

ttatgtttgt attacccaac cgaagcagca acagaaataa atgataatgc atggaaggat      300

acactttctc aactattttt aactaaagga tggccgacag gatctattta ttttaaagat      360

tatactgata ttgcctcgtt ttcagttgat ccacaactgt actgtgatta taatttggta      420

ttaatgaaat acgacgctac actacaactg gacatgtctg aactagcaga tttgttactt      480

aatgagtggt tatgtaatcc tatggatatt actttgtatt attatcaaca aactgatgag      540

gcaaataaat ggatttcaat gggatcatct tgtaccataa aggtatgtcc actaaatacg      600

caaacattag gaattgggtg tctaactact gatacaaaca cgttcgaaga agttgcaaca      660

gctgaaaaat tagtgattac tgacgttgta gatggggtca atcataaatt gaacgtgacg      720

acaaacactt gtacgattag aaattgtaaa aaattaggac caagggaaaa cgtagcagtt      780

atacaggttg gtggctcaga tgtacttgac ataacagctg atcctacgac agcgccacga      840

acagaaagaa tgatgcgagt gaattggaag aaatggtggc aagtatttta tacaatagtt      900

gactacgtga atcaaattgt gcaagcgatg tccaaaagat cgagatcgtt aaattctgct      960

gcattttact acagggtata g                                                981


<210>  64
<211>  326
<212>  PRT
<213>  artificial

<220>
<223>  MA104-adapated RV3 VP7

<400>  64

Met Tyr Gly Ile Glu Tyr Thr Thr Val Leu Thr Phe Leu Ile Ser Ile 
1               5                   10                  15      


Ile Leu Leu Asn Tyr Val Leu Lys Ser Leu Thr Arg Ile Met Asp Phe 
            20                  25                  30          


Ile Ile Tyr Arg Phe Leu Leu Ile Ile Val Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ala Gln Asn Tyr Gly Ile Asn Leu Pro Ile Thr Gly Ser Met Asp 
    50                  55                  60                  


Thr Pro Tyr Thr Asn Ser Thr Arg Glu Glu Val Phe Leu Thr Ser Thr 
65                  70                  75                  80  


Leu Cys Leu Tyr Tyr Pro Thr Glu Ala Ala Thr Glu Ile Asn Asp Asn 
                85                  90                  95      


Ala Trp Lys Asp Thr Leu Ser Gln Leu Phe Leu Thr Lys Gly Trp Pro 
            100                 105                 110         


Thr Gly Ser Ile Tyr Phe Lys Asp Tyr Thr Asp Ile Ala Ser Phe Ser 
        115                 120                 125             


Val Asp Pro Gln Leu Tyr Cys Asp Tyr Asn Leu Val Leu Met Lys Tyr 
    130                 135                 140                 


Asp Ala Thr Leu Gln Leu Asp Met Ser Glu Leu Ala Asp Leu Leu Leu 
145                 150                 155                 160 


Asn Glu Trp Leu Cys Asn Pro Met Asp Ile Thr Leu Tyr Tyr Tyr Gln 
                165                 170                 175     


Gln Thr Asp Glu Ala Asn Lys Trp Ile Ser Met Gly Ser Ser Cys Thr 
            180                 185                 190         


Ile Lys Val Cys Pro Leu Asn Thr Gln Thr Leu Gly Ile Gly Cys Leu 
        195                 200                 205             


Thr Thr Asp Thr Asn Thr Phe Glu Glu Val Ala Thr Ala Glu Lys Leu 
    210                 215                 220                 


Val Ile Thr Asp Val Val Asp Gly Val Asn His Lys Leu Asn Val Thr 
225                 230                 235                 240 


Thr Asn Thr Cys Thr Ile Arg Asn Cys Lys Lys Leu Gly Pro Arg Glu 
                245                 250                 255     


Asn Val Ala Val Ile Gln Val Gly Gly Ser Asp Val Leu Asp Ile Thr 
            260                 265                 270         


Ala Asp Pro Thr Thr Ala Pro Arg Thr Glu Arg Met Met Arg Val Asn 
        275                 280                 285             


Trp Lys Lys Trp Trp Gln Val Phe Tyr Thr Ile Val Asp Tyr Val Asn 
    290                 295                 300                 


Gln Ile Val Gln Ala Met Ser Lys Arg Ser Arg Ser Leu Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Tyr Tyr Arg Val 
                325     


<210>  65
<211>  1062
<212>  DNA
<213>  artificial

<220>
<223>  Vero-adapated RV3 VP7

<400>  65
ggctttaaaa gagagaattt ccgtctggct agcggttagc tccttttaat gtatggtatt       60

gaatatacca cagttttgac ctttttgata tcaattatat tgttgaatta cgtactcaaa      120

tcattaacta gaataatgga ctttattatc tacagatttc ttttgattat agttatactg      180

tcaccactcc ttaatgcaca aaattatgga ataaatcttc cgattactgg atcaatggac      240

acaccatata cgaactcaac gcgagaggaa gtattcctaa cttcgacttt atgtttgtat      300

tacccaaccg aagcagcaac agaaataaat gataatgcat ggaaggatac actttctcaa      360

ctatttttaa ctaaaggatg gccgacagga tctatttatt ttaaagatta tactgatatt      420

gcctcgtttt cagttgatcc acaactgtac tgtgattata atttggtatt aatgaaatac      480

gacgctacac tacaactgga catgtctgaa ctagcagatt tgttacttaa tgagtggtta      540

tgtaatccta tggatattac tttgtattat tatcaacaaa ctgatgaggc aaataaatgg      600

atttcaatgg gatcatcttg taccataaag gtatgtccac taaatacgca aacattagga      660

attgggtgtc taactactga tacaaacacg ttcgaagaag ttgcaacagc tgaaaaatta      720

gtgattactg acgttgtaga tggggtcaat cataaattga acgtgacgac aaacacttgt      780

acgattagaa attgtaaaaa attaggacca agggaaaacg tagcagttat acaggttggt      840

ggctcagatg tacttgacat aacagctgat cctacgacag cgccacgaac agaaagaatg      900

atgcgagtga attggaagaa atggtggcaa gtattttata caatagttga ctacgtgaat      960

caaattgtgc aagcgatgtc caaaagatcg agatcgttaa attctgctgc attttactac     1020

agggtatagg tatagcttag attagaattg tatgatgtga cc                        1062


<210>  66
<211>  326
<212>  PRT
<213>  artificial

<220>
<223>  Vero-adapated RV3 VP7

<400>  66

Met Tyr Gly Ile Glu Tyr Thr Thr Val Leu Thr Phe Leu Ile Ser Ile 
1               5                   10                  15      


Ile Leu Leu Asn Tyr Val Leu Lys Ser Leu Thr Arg Ile Met Asp Phe 
            20                  25                  30          


Ile Ile Tyr Arg Phe Leu Leu Ile Ile Val Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ala Gln Asn Tyr Gly Ile Asn Leu Pro Ile Thr Gly Ser Met Asp 
    50                  55                  60                  


Thr Pro Tyr Thr Asn Ser Thr Arg Glu Glu Val Phe Leu Thr Ser Thr 
65                  70                  75                  80  


Leu Cys Leu Tyr Tyr Pro Thr Glu Ala Ala Thr Glu Ile Asn Asp Asn 
                85                  90                  95      


Ala Trp Lys Asp Thr Leu Ser Gln Leu Phe Leu Thr Lys Gly Trp Pro 
            100                 105                 110         


Thr Gly Ser Ile Tyr Phe Lys Asp Tyr Thr Asp Ile Ala Ser Phe Ser 
        115                 120                 125             


Val Asp Pro Gln Leu Tyr Cys Asp Tyr Asn Leu Val Leu Met Lys Tyr 
    130                 135                 140                 


Asp Ala Thr Leu Gln Leu Asp Met Ser Glu Leu Ala Asp Leu Leu Leu 
145                 150                 155                 160 


Asn Glu Trp Leu Cys Asn Pro Met Asp Ile Thr Leu Tyr Tyr Tyr Gln 
                165                 170                 175     


Gln Thr Asp Glu Ala Asn Lys Trp Ile Ser Met Gly Ser Ser Cys Thr 
            180                 185                 190         


Ile Lys Val Cys Pro Leu Asn Thr Gln Thr Leu Gly Ile Gly Cys Leu 
        195                 200                 205             


Thr Thr Asp Thr Asn Thr Phe Glu Glu Val Ala Thr Ala Glu Lys Leu 
    210                 215                 220                 


Val Ile Thr Asp Val Val Asp Gly Val Asn His Lys Leu Asn Val Thr 
225                 230                 235                 240 


Thr Asn Thr Cys Thr Ile Arg Asn Cys Lys Lys Leu Gly Pro Arg Glu 
                245                 250                 255     


Asn Val Ala Val Ile Gln Val Gly Gly Ser Asp Val Leu Asp Ile Thr 
            260                 265                 270         


Ala Asp Pro Thr Thr Ala Pro Arg Thr Glu Arg Met Met Arg Val Asn 
        275                 280                 285             


Trp Lys Lys Trp Trp Gln Val Phe Tyr Thr Ile Val Asp Tyr Val Asn 
    290                 295                 300                 


Gln Ile Val Gln Ala Met Ser Lys Arg Ser Arg Ser Leu Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Tyr Tyr Arg Val 
                325     


